During analysis of pyruvate kinase distribution in developing guinea-pig liver it was observed that a substantial proportion of the activity remained associated with the microsomal membrane fraction ('microsomes'). Although some of this could be removed by washing with sucrose, the majority required detergent treatment for liberation, and even then at least one-half remained attached to the mic...

Este trabalho analisa o perfil das relações intergovernamentais promovidas pelo Departamento Penitenciário Nacional (DEPEN) para com os governos estaduais entre anos de 2006 a 2016. Partimos da hipótese que foram estabelecidas estratégias distintas em torno criação programas federais e vinculação desses ao repasse recursos financeiros via Fundo (FUNPEN). Por um lado, buscou-se coordenação feder...

The preferential growth of B16 melanoma métastases in specific organs was studied. Following the i.v. injection of B16 melanoma cells into syngeneic C57BL/6 mice, tumor growths developed in the in situ lungs and in grafts of pulmonary or ovarian tissue implanted either s.c. or i.m. In contrast, neoplastic lesions failed to develop in control grafts of similarly im planted renal tissue or at th...

Information-driven networks include a large category of net-working systems, where network nodes are aware of infor-mation delivered and thus can not only forward data packetsbut may also perform information processing. In many sit-uations, the quality of service (QoS) in information-drivennetworks is provisioned with the redundancy in information.Traditional performance...

Transcription factors p53 and nuclear factor kappaB (NF-kappaB) have been implicated in apoptosis induced by DNA-damaging agents, but the relationship between these two factors at the molecular level is largely unknown. We have isolated apoptosis-resistant mutant sublines from a radiosensitive mouse lymphoma 3SB cell line that undergoes p53-depen-dent apoptosis after X-ray irradiation, and we h...

The microsomal fraction of sheep vesicular glands has been found to oxygenate 1,3-diphenylisobenzofuran, luminol, and the carcinogenic hydrocarbon benzopyrene when incubated with arachidonic acid. The oxygenations demonstrate an absolute dependence on enzyme and fatty acid and can be completely inhibited by indomethacin and 2,3-dimercaproptopanol, inhibitors of prostaglandin synthetase. The oxy...

Cell fractionation experiments indicate that NAD glycohydrolase (EC 3.2.2.6) is a constituent enzyme of both the microsomal (endoplasmic reticulum) and plasmalemma membrane of the rat hepatocyte. The enzyme was solubilized by steapsin digestion from both fractions and subsequently purified -2000 over the homogenate and -500 over the microsomal fraction by successive DEAE-cellulose, Sephadex G-1...

A controller is an environment for a system that achieves a par ticular control objective by providing inputs to the system without constrain ing the choices of the system For synchronous systems where system and controller make simultaneous and interdependent choices the notion that a controller must not constrain the choices of the system can be formalized by type systems for composability In...

The effect of enzymatically generated reduced oxygen metabolites on the activity of hepatic microsomal glutathione S-transferase activity was studied to explore possible physiological regulatory mechanisms of the enzyme. Noradrenaline and the microsomal cytochrome P-450-dependent monooxygenase system were used to generate reduced oxygen species. When noradrenaline (greater than 0.1 mM) was incu...

A mouse mast cell tumor microsomal preparation which catalyzes the incorporation of 35S0., from 3’-phosphoadenosine 5’-phosphosulfate-33S into microsomal heparin has been described. This enzyme preparation is the same preparation that previously has been shown to catalyze the incorporation of sugars into a microsomal glycosaminoglycan related to heparin. It is suggested that polysaccharide poly...