BACKGROUND MicroRNAs are small noncoding RNAs that play critical roles in regulation of gene expression in wide array of tissues including the ovary through sequence complementarity at post-transcriptional level. Tight regulation of multitude of genes involved in ovarian development and folliculogenesis could be regulated at transcription level by these miRNAs. Therefore, tissue specific miRNAs...

MicroRNAs (miRNAs) are small non-coding regulatory RNAs molecules with a size of approximately 22 nucleotides that are implicated in regulating gene expression at the post-transcriptional regulatory levels. Inflammatory disorders especially autoimmune diseases (ADs) occur from an abnormal immune response of body against cells of their own specific tissues or multiple organ systems leading to ch...

This study was aimed to identify miRNAs of corpus luteum (CL) in buffaloes during pregnancy. For this study, CL (n=2) were collected from gravid uteri of buffalo and RNA was isolated. Following this, the purity and integrity of RNA was checked and used for deep sequencing using Illumina Hiseq 2500 platform. The reads’ quality was checked prior to in silico analyses viz. identification of conser...

MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific and regulate many cellular processes. Neuroinflammation plays pivotal role in occurrence development of multiple central nervous system (CNS) diseases. The miRNAs enhance restrict neuroinflammatory signaling pathways CNS diseases is an emerging important research area, including neurodegenerative d...

Alzheimer’s disease (AD), the most common dementia with symptom of deterioration memory and cognitive functions, becomes one prevalent threats globally. Tau hyperphosphorylation is major risk factors AD. At present, there no effective treatment or quick diagnostic methods for pre-clinical stage this disease. MicroRNAs (miRNAs) are small (20-25bp) non-coding, double stranded RNA molecule. They m...

MicroRNAs are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular messenger RNAs. They are frequently dysregulated in cancer and have shown great potential as tissue-based markers for cancer classification and prognostication. microRNAs are also present in extracellular human body fluids such as serum, plasma...

Abstract MicroRNAs (miRNAs) are essential nonprotein-coding genes. In a range of organisms, miRNAs has been reported to play an role in regulating gene expressions at post-transcriptional level. They participate most the stress responsive processes plants. Drought is ultimate abiotic that affects crop production. Therefore understanding drought responses improve production agricultural crops. T...

The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one first known oncoviruses to encode viral microRNAs (miRNAs), these molecules were found interact host targets. miRNAs modulate biological processes that are critical for carcinogenesis, contributing cell t...

Abstract Post-transcriptional gene silencing mediated by microRNAs (miRNAs) modulates numerous developmental and stress response pathways. For the last two decades, HASTY (HST), ortholog of human EXPORTIN 5, was considered to be a candidate protein that exports plant miRNAs from nucleus cytoplasm. Here, we report HST functions in miRNA pathway independent its cargo-exporting activity Arabidopsi...

A number of web tools are available for the prediction and identification of target microRNAs (miRNAs). The choice, availability, validity and selection of an optimal yet appropriate tool are a challenge for the design of high throughput assays with promising miRNA targets. The current trends and challenges for target microRNAs (miRNAs) prediction, identification and selection is described in t...