Focal chondral lesions of the glenohumeral joint, though less common than chondral defects in the knee or ankle, can be a significant source of pain in an active population. For patients in whom nonsurgical management fails, promising results have been reported after arthroscopic microfracture surgery to treat such lesions. However, microfracture leads to growth of fibrocartilage tissue and is ...

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in field pain therapy. Thanks to bonding chitosan mucosa and its permeability-enhancing effect, it is excellent choice formulate microspheres for increase drug bioavailability. aim our work includes preparation spray-dried cross-linked non-cross-linked chitosan-based de...

Micronization of minocycline hydrochloride dissolved in ethanol and with supercritical carbon dioxide as antisolvent was successfully performed using a recently built SAS apparatus. Amorphous particles of minocycline ranging from 100 to 1000 nm (depending on the operating conditions) were obtained. The mean particle size and the particle size distribution were determined by Dynamic Light Scatte...

The study evaluates the micronized poloxamers Lptrol micro127 (poloxamer 407) and Lptrol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for friction, plasticity, ejection force, tensile strength of tablets, and d...

UNLABELLED SUMMARY QUESTION: Is vaginal progesterone gel equivalent to vaginal micronized progesterone tablets concerning ongoing pregnancy rate and superior concerning patient convenience when used for luteal support after IVF/ICSI? SUMMARY ANSWER Equivalence of treatments in terms of ongoing live intrauterine pregnancy rate has not been demonstrated; the 95% confidence interval (CI) for the...

Improving oral bioavailability of drugs given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. To address this encumbrance, ionotropic gelation technique has attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by engineering spherical agglomerates. Spherical beads...

Epidemiological and psychophysiological data suggest that groups that differ in reproductive hormones and stress responses also differ in risk for cardiovascular disease. To evaluate the effects of hormone therapy on women's cardiovascular responses to laboratory stressors, 89 healthy postmenopausal women were tested twice, before and after exposure for about 8 weeks to one of the five conditio...

An experiment was done to determine manure output, N and P excretion, and apparent digestibilities of AA, CP, P, and DM in growing pigs fed barley-based diets containing micronized or raw peas with or without supplementation with enzyme containing primarily beta-glucanase and phytase (Biogal S+). Eight barrows (21.5 +/- 1.2 kg of initial BW) fitted with T-cannulas at the distal ileum were used ...

BACKGROUND The purpose of this study was to develop a method for targeted delivery of 10-hydroxycamptothecin (HCPT)-loaded nanoparticles (NPs) to cancer cells. METHODS We first used a supercritical antisolvent process to prepare micronized HCPT (nHCPT), and then folate-conjugated human serum albumin (HSA) nHCPT-loaded NPs (FA-HSA-nHCPT-NPs) were prepared using a NP-coated method combined with...

in this study, selenium was recovered from an industrial dust. after the purification process, the researchers were able to prepare selenium micro powder. the objective of this study was to prepare selenium nano particles by water solution phase method from the micro powders. the results showed that selenium micronized powder and nano particles had high purity. the obtained nanoparticles were t...