Biomolecular interactions over the surface of a microcantilever can produce its bending motion via changes of the surface stress, which is referred to nanomechanical response. Here, we have studied the interaction forces responsible for the bending motion during the formation of a self-assembled monolayer of thiolated 27-mer single-stranded DNA on the gold-coated side of a microcantilever and d...

Fundamental research is being conducted to develop sensors for cesium and strontium that can be used in real-time to characterize highlevel waste (HLW) process streams. Two fundamentally different approaches are being pursued, having in common the dependence on highly selective molecular recognition agents. In one approach, an array of chemically selective sensors with sensitive fluorescent pro...

Ligand-directed targeting and capturing of cancer cells is a new approach for detecting circulating tumor cells (CTCs). Ligands such as antibodies have been successfully used for capturing cancer cells and an antibody based system (CellSearch(®)) is currently used clinically to enumerate CTCs. Here we report the use of a peptide moiety in conjunction with a microcantilever array system to selec...

The main causes for the deflection of microcantilevers embedded in micromechanical biodetection systems are investigated. The primary deflection due to the chemical reaction between the analyte molecules and the receptor coating, which produces surface stresses on the receptor side is analyzed. Oscillating flow conditions, which are the main source of turbulence, are found to produce substantia...

abstract: application of atomic force microscope as a manipulator for pushing-based positioning of nano-particles has been of considerable interest during recent years. however a detailed modeling of the interaction forces and control on the afm tip is important for prosperous manipulation control, a reliable control of the afm tip position during the afm-based manipulation process is a main is...

In this paper, we study the dynamical behavior of a microcantilever-sample system that forms the basis for the operation of atomic force microscopes (AFM). We model the microcantilever by a single mode approximation and the interaction between the sample and cantilever by a van der Waals (vdW) potential. The cantilever is vibrated by a sinusoidal input, and its de#ection is detected optically. ...

We have investigated chemical reactions between adsorbed water and active sites on a silicon nitride surface as a function of temperature and relative humidity using microcantilevers. Effects that might produce a change in the response of the microcantilever, such as a mass adsorption, surface tension of the adsorbed water, and changes in thermal conductivity, were systematically investigated. ...

This paper investigates the design optimization of an electrostatically actuated microcantilever resonator that operates in air. The nonlinear effects of electrostatic actuation and air damping make the structural dynamics modeling more complex. There is a need for an efficient way to simulate the system behavior so that the design can be more readily optimized. This paper describes an efficien...

The use of microcantilever arrays for microbial growth detection provides a rapid and reliable technique for monitoring growth in industrial and clinical applications. Improving the reproducibility and sensitivity of this technique is of great importance. Ink-jet printing has been successfully used in microfabrication and biofabrication due to its high precision; however, only a few microbe-bas...

Characterization and control of proteolysis of peptides by specific cellular protease is a priori requisite for effective drug discovery. Here, we report the nanomechanical, in situ monitoring of proteolysis of peptide chain attributed to protease (Cathepsin B) by using a resonant nanomechanical microcantilever immersed in a liquid. Specifically, the detection is based on measurement of resonan...