Wehave studied the microbial transformation of griseofulvin (I) by Cephalosporium curtipes and the formation of two more polar metabolites was observed in a proportion of 10:1. The compounds have been identified as (+)-5'-hydroxygriseofulvin (axial) (II) and G'-hydroxymethylgriseofulvin (III) (Fig. 1). The microbial transformation of griseofulvin was performed by a 48-hour-old culture of Cephal...
