We report on the first detailed atomic-scale studies of micelle fission in micellar systems consisting of anionic sodium dodecyl sulfate with explicit solvent. We demonstrate a new micelle fission pathway for ionic surfactants and show how micelle fission can be induced by varying the ionic concentration. We argue that this fission pathway proceeds through an initial Rayleigh instability driven...

The crucial balance of stability in blood-circulation and tumor-specific delivery has been suggested as one the challenges for effective bench-to-bedside translation nanomedicines (NMs). Herein, we developed a supramolecularly enabled tumor-extracellular (Tex) pH-triggered NM that can maintain micellar structure with entrapped-drug during systemic circulation progressively release drug tumor by...

this work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. in-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

Micelle gel is a radiochromic hydrogel with the potential to be used as a three dimensional (3D) radiation dosimeter. Since an ideal dosimeter should present water equivalent properties, in this study the water equivalence of two formulations of micelle gel has been investigated by calculating electron density, effective atomic number, fractional interaction probabilities, mass attenuation coef...

In this paper, the dynamic assembly of toroidal micelle structures of amphiphilic triblock copolymers in dilute solution has been investigated using dissipative particle dynamics simulations. The amphiphilic molecule is represented by a coarse-grained model, which contains hydrophilic and hydrophobic particles. Some microstructures of complex morphology having toroidal micelles have been observ...

A distinct tadpole-shaped nanostructure characterized by a spherical head and an extended shaft was identified in a single plasmid DNA (pDNA)-based polymeric micelle. The tadpole-shaped structure was constructed by adding anionic chondroitin sulfate (CS) to the rod-shaped polyplex micelle containing a single pDNA molecule packaged by the PEG-polycation block copolymer through their electrostati...

Methylene Blue, Reversed Micelles, Water Content, Solubilization The solubilization of methylene blue in dodecylammonium propionate reversed micelles in cyclohexane depended strongly on the solubilized water content. Methylene blue solubilized in the micelle of which head groups are not completely hydrated by bound water exhibited the new absorption bands at 495 and 270 nm, but these bands did ...

Scavenger receptors (SRs) like cluster determinant 36 (CD36) and SR class B type I (SR-BI) play a debated role in lipid transport across the intestinal brush border membrane. We used surface plasmon resonance to analyze real-time interactions between the extracellular protein loops and various ligands ranging from single lipid molecules to mixed micelles. Micelles mimicking physiological struct...

To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, ...