the effects of cholecystokinin (cck) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. in the present work, subcutaneous (sc) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. administration of ccka receptor antagonist mk-329 (0.5-1.5 mg/kg), cckb receptor antagonist l-365, 260 (0.5-1.5 mgl kg) and cck recept...

in the present study the effects of both cck receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. m orphine induced dose-dependent antinociception in mice. the response of morphine was potentiated by sulfated cholecystokinin-8 (cck-8s) but not by unsulfated cholecystokinin-8 (cck-8u). the cck receptor antagonists mk-329 and l-365, ...

background and objective: regarding inefficiency of common drugs used for alleviation of anxiety due to narcotics withdrawal, the present study was evaluated methadone and haloperidol co-drugs therapy on anxiety due to morphine withdrawal. materials and methods: ninety eight nmri male mice were divided into acute and chronic experimental groups. then, each group was divided into 7 subgroups: sa...

objective : in this study, the effects of estradiol valerate and raloxifenea selective estrogen receptor modulator; (serm) on morphine induced sensitization were examined in mice memory, according to the step-down passive avoidance task. method: the mice received morphine or estradiol and raloxifene for three days alone or in combination with morphine. after a drug free period of 5 days, the su...

Calina papaya leaf is an Indonesian plant type that has the potential to be used as a medicinal plant. Phytochemical compounds found in leaves act antifertility agents. The research aimed study effect of ethanol extract on estrus cycle and uterine morphology wistar rats. experiment lasted 30 days involved 25 female treatment consisted 5 groups, namely K (distilled water), K+ (contraceptive pill...

teratomas that occur in the uterus are exceedingly rare. to the best of our knowledge there are only 22 cases of mature and immature teratomas of the uterus and cervix thus far reported in the literature. we report an unusual case of mature cystic teratoma of the uterine surface with well-differentiated adenocarcinoma of the endometrium and uterine leiomyoma along with a mature cystic teratoma ...

Morphine-induced itch is mediated by a specific population of dynorphin-expressing spinal inhibitory neurons in mice.

OBJECTIVES The objective of the study is comparing pathohistological picture and test results of the activity of the enzymes of the anti-oxidative protection -cytoplasmic super-oxide dismutase (CuZnSOD) from the blood and endometrium in the promotion of the progression or regression of the hyperplasia and endometrium carcinoma. MATERIALS AND METHODS The study has been carried out on 70 patien...

Objective: To evaluate the potential of Gracilaria changii extract in ameliorating adverse effects bisphenol A.Methods: The antioxidant capacity extracted using different solvents (methanol, ethanol, and aqueous) was studied. mice were administered by oral gavage with A (60 mg/kg body weight) for 6 weeks or without aqueous extract. Thereafter, either euthanized histology immunohistochemistry st...

Background: Nicotine exposure causes impaired fertility , ovarian and uterus dysfunction. The pineal hormone melatonin is known as an antioxidant agent. The aim of this study was to investigate the possible protective role of exogen melatonin on altered ovary and endometrium with nicotine. Materials and Methods: Female adult NMRI mice were divided into four groups. The control group received ve...