نتایج جستجو برای: mica gene

تعداد نتایج: 1144373  

2015
Fazal Shirazi Russel E. Lewis Dimitrios P. Kontoyiannis

We hypothesized that the cell wall inhibitor micafungin (MICA) induces apoptosis in both MICA-susceptible (MICA-S) and MICA-non-susceptible (MICA-NS) Candida parapsilosis. Antifungal activity and apoptosis were analyzed in MICA-S and MICA-NS C. parapsilosis strains following exposure to micafungin for 3 h at 37°C in RPMI 1640 medium. Apoptosis was characterized by detecting phosphatidylserine e...

Journal: :iranian journal of immunology 0
shirin farjadian department of immunology shahrzad rahimifar department of immunology nasrollah erfani shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran ramin lotfi institute of transfusion medicine, university of ulm, ulm, germany

background: a possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of nkg2d ligands on tumor cells. although the expression of mhc class i chain-related protein a and b (mica/b) has previously been reported in different carcinomas, there is no information about mica/b expression in liposarcomas. objective: to investigate mica/b induction in a human liposarcoma...

2015
Xiao Gong Andrew Kozbial Lei Li

Morphology of BMIM FAP on the heated mica surface Mica was cleaved and heat treated in an conventional oven at 120 C for 1 h. Afterwards, the mica was dip-coated with 0.01 g/L and 0.001 g/L BMIM FAP/Vertrel (2,3-dihydrodecafluoropentane) solution, respectively. The average thickness of the resulting BMIM FAP nanofilms is estimated to be in the order of angstrom or lowerS1. The topography of BM...

2010
Klas I. Udekwu

BACKGROUND The small RNA (sRNA) MicA has been shown to post-transcriptionally regulate translation of the outer membrane protein A (OmpA) in Escherichia coli. It uses an antisense mechanism to down-regulate OmpA protein synthesis and induce mRNA degradation. MicA is genomically localized between the coding regions of the gshA and luxS genes and is divergently transcribed from its neighbours. Tr...

1997
Daniel P. Snowden-Ifft Andrew J. Westphal

Mica can store (for > 1 Gy) etchable tracks caused by atoms recoiling from WIMPs. Because a background from fission neutrons will eventually limit this technique, a unique signature for WIMPs in ancient mica is needed. Our motion around the center of the Galaxy causes WIMPs, unlike neutrons, to enter the mica from a preferred direction on the sky. Mica is a directional detector and despite the ...

2013
Charlotte A. Henderson Helen A. Vincent Carlanne M. Stone Jack O. Phillips Peter D. Cary Darren M. Gowers Anastasia J. Callaghan

MicA is a small non-coding RNA that regulates ompA mRNA translation in Escherichia coli. MicA has an inhibitory function, base pairing to the translation initiation region of target mRNAs through short sequences of complementarity, blocking their ribosome-binding sites. The MicA structure contains two stem loops, which impede its interaction with target mRNAs, and it is thought that the RNA cha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Mair Thomas Jessica M Boname Sarah Field Sergey Nejentsev Mariolina Salio Vincenzo Cerundolo Mark Wills Paul J Lehner

Natural killer (NK) cells are important early mediators of host immunity to viral infections. The NK activatory receptors NKG2D and NKp80, both C-type lectin-like homodimeric receptors, stimulate NK cell cytotoxicity toward target cells. Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) down-regulates MHC class I molecules to avoid detection by cytotoxic T lymphocytes but...

2014
Liang Fang Jiuyu Gong Ying Wang Rongrong Liu Zengshan Li Zhe Wang Yun Zhang Chunmei Zhang Chaojun Song Angang Yang Jenny P -Y Ting Boquan Jin Lihua Chen

BACKGROUND MICA/B are major ligands for NK cell activating receptor NKG2D and previous studies showed that the serum level of soluble MICA (sMICA) is an independent prognostic factor for advanced human hepatocellular carcinoma. However, the correlation between cellular MICA/B expression pattern and human hepatocellular carcinoma progression has not been well explored. The unfolded protein respo...

Journal: :Journal of immunology 2009
Lars Andresen Karen Aagaard Hansen Helle Jensen Stine Falsig Pedersen Peter Stougaard Helle Rüsz Hansen Jesper Jurlander Søren Skov

We found that propionic acid secreted from propionibacteria induces expression of the NKG2D ligands MICA/B on activated T lymphocytes and different cancer cells, without affecting MICA/B expression on resting peripheral blood cells. Growth supernatant from propionibacteria or propionate alone could directly stimulate functional MICA/B surface expression and MICA promoter activity by a mechanism...

2012
Jiaxu Hong Ting Qiu Tingting Qian Gang Li Xiaobo Yu Junyi Chen Qihua Le Xinghuai Sun Jianjiang Xu

BACKGROUND Major-histocompatibility-complex class I-related chain A (MICA) antigens are the ligands of NKG2D, which is an activating or coactivating receptor expressed on human NK cells and CD8+T cells. We sought to determine whether MICA expression in human corneal epithelium (HCE) could affect the cytotoxicity mediated by NK cells or CD8+T cells. METHODS Cell cultures of HCE were harvested ...

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