نتایج جستجو برای: mgxni1 xo

تعداد نتایج: 1552  

Journal: :Journal of medical genetics 1992
C Gicquel S Cabrol H Schneid F Girard Y Le Bouc

Turner's syndrome is a common disorder which occurs in around 1/3000 live births in girls. Diagnostic use of polymorphic DNA markers for the X chromosome could help to reduce the number of time consuming karyotype analyses needed. The M27 beta probe maps on the X chromosome to Xcen-Xp11-22 and in 83% of female subjects detects heterozygosity with multiallelic polymorphism. In Southern blotting,...

2006
Elena Daghini Alejandro R. Chade James D. Krier Daniele Versari Amir Lerman Lilach O. Lerman

Daghini, Elena, Alejandro R. Chade, James D. Krier, Daniele Versari, Amir Lerman, and Lilach O. Lerman. Acute inhibition of the endogenous xanthine oxidase improves renal hemodynamics in hypercholesterolemic pigs. Am J Physiol Regul Integr Comp Physiol 290: R609–R615, 2006. First published November 10, 2005; doi:10.1152/ajpregu.00436.2005.—Hypercholesterolemia (HC), a major risk factor for onse...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2000
S Wada-Takahashi K Tamura

With conventional intracellular recording methods, we investigated the mechanism of actions of reactive oxygen species (ROS) derived from hypoxanthine and xanthine oxidase (HX/XO) reactions on AH/type 2 myenteric neurons in the guinea pig distal colon. Of the 54 neurons to which HX/XO was applied, 32 neurons showed a transient membrane hyperpolarization(s) followed by a long-lasting membrane de...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
Robert P Jankov Crystal Kantores Jingyi Pan Jaques Belik

Xanthine oxidase (XO)-derived reactive oxygen species (ROS) formation contributes to experimental chronic hypoxic pulmonary hypertension in adults, but its role in neonatal pulmonary hypertension has received little attention. In rats chronically exposed to hypoxia (13% O(2)) for 14 days from birth, we examined the effects of ROS scavengers (U74389G 10 mg.kg(-1).day(-1) or Tempol 100 mg.kg(-1)....

2011
Ziqing Duan Aurelien Du Pasquier Yicheng Lu Yi Xu Eric Garfunkel

MgxZn1 xO (0rxr0.13) films grown by metal-organic chemical vapor deposition (MOCVD) were chosen as the n-type semiconductor layer forming a heterojunction with electrodeposited p-type cuprous oxide (Cu2O) for photovoltaic applications in this study. We investigated the effects of Mg contents (x) on the performance of Ag–Cu2O–MgxZn1 xO–fluorine-doped tin oxide (FTO)-glass heterojunction solar ce...

Journal: :Gut 1999
G Schimpl M A Pabst G Feierl A Kuesz H Ozbey S Takahashi M E Höllwarth

BACKGROUND Bacterial translocation (BT) plays a major role in the pathophysiological process of spontaneous infections in portal hypertension (PH) and cholestatic jaundice. The major mechanisms promoting BT in experimental animal models are the disruption of the intestinal ecological equilibrium and disruption of the intestinal mucosal barrier. The enzymes xanthine dehydrogenase (XD) and xanthi...

2015
Jean Monlong Caroline Meloche Guy Rouleau Patrick Cossette Simon L. Girard Guillaume Bourque

Department of Human Genetics, McGill University, Montréal, H3A 1B1, Canada McGill University and Génome Québec Innovation Center, Montréal, H3A 1A4, Canada Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, H2X 0A9, Québec, Canada. Montreal Neurological Institute, McGill University, Montréal, H3A 2B4, Québec, Canada. Département des sciences fondamentales, Universi...

Journal: :Circulation research 2002
Walter F Saavedra Nazareno Paolocci Marcus E St John Michel W Skaf Garrick C Stewart Jin-Sheng Xie Robert W Harrison Joshua Zeichner Daniel Mudrick Eduardo Marbán David A Kass Joshua M Hare

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative stress and critically depends on nitric oxide synthase (NOS) activity, reflecting a balance between generation of nitric oxide (NO) and reactive oxygen species. In dogs with pacing-induced heart failure (HF), ascorbate ...

2014
Kaustubh S. Gadave Santanu Panda Surender Singh Shalini Kalra Dhruba Malakar Ashok K. Mohanty Jai K. Kaushik

BACKGROUND Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. XOR also produces free radicals serving as second messenger and microbicidal agent. Large variation in the XO activity has been observed among various species. Both...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
S Persad V Elimban J Kaila N S Dhalla

To assess the effects of oxyradicals on cardiac beta-adrenoceptors, G-proteins and adenylyl cyclase, rat heart membranes were incubated with xanthine (X) plus xanthine oxidase (XO) for different intervals. The basal as well as forskolin-, NaF-, 5'-guanylylimidodiphosphate and isoproterenol-stimulated adenylyl cyclase activities showed an increase at 10 min and a decrease at 30 min of incubation...

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