Neural stem cell-based treatment holds a new therapeutic opportunity for neurodegenerative disorders. Here, we investigated the effect of methylene blue on proliferation and differentiation of rat neural progenitor cells (NPCs) both in vitro and in vivo. We found that methylene blue inhibited proliferation and promoted quiescence of NPCs in vitro without affecting committed neuronal differentia...

Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate allergic hypersensitivity reaction to methylene blue-treated plasma transfusion....

Background : Effluents containing synthetic dyes are hazardous to ecological systems and public health. Methylene blue is an important chemical aromatic dye which commonly used in textile industries. Due to being aromatic, it is often toxic, carcinogenic and mutagenic. The goal of this study was to investigate the efficiency of ZnO nano particles photocatalytic process for decolorization of met...

Background & objectives: The release of dyestuff wastewaters produced in textile industry into receiving waters affects both human health and the environment. The aim of this study was to investigate the efficiency of a photocatalytic UV/persulfate process in removal of methylene blue and acid green 3 dyes from aqueous solutions. Methods: The current study was an experimental study, in which t...

Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study was to evaluate the effect of methylene blue in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, methylene blue inhibited angiogenesis in a concentration-dependent manner. In...

In the present work, the effect of initial pH of methylene blue solution on the kinetics of dye sorption from synthetic aqueous solution by a natural waste material namely: orange peels, was studied. Kinetic data were measured in batch conditions. Methylene blue uptake was time contact and solution initial pH dependent. Maximum dye sorption was found to occur at initial pH 9. Two simplified kin...

The red blood cell hexose monophosphate shunt (HMS) and proteolytic responses to several concentrations of Methylene Blue or sodium nitrite were measured. The results suggested two distinct mechanisms for activation of the HMS: (1) nitrite treatment increased HMS activity in response to oxidative challenge to red cell protein; (2) Methylene Blue treatment activated HMS without injurious oxidati...

This work describes the photocatalytic removal of methylene blue from aqueous solution by titanium dioxide nanoparticles under ultraviolet irradiation in a batch system. The effect of operational parameters such as irradiation time, nano titanium dioxide dosage, pH and initial methylene blue concentration were analyzed and optimized by response surface methodology in the nano titanium dioxide/u...

Methylene blue is an intravenously administered agent that may potentiate serotonin syndrome. The usage of methylene blue to evaluate ureters for injuries and patency during urological surgeries is recognized as common practice. However, there is no mention of serotonin syndrome caused by methylene blue in urological literature or for urological surgery. We report the first urological case in o...

A significant decrease in methylene blue reducing power of plasma from patients with malignan t neoplastic disease was previously reported (1). At tha t time it was suggested that change in a reducing group of the albumin molecule was a likely source of this alteration. Similar conclusions were reported also by Savignac and associates (7) as the result of analogous studies. In an a t t empt to ...