The conditional formal potential, E°′of Methyldopa has been studied by cyclic voltammetry at the surface of activated glassy carbon electrode (AGCE) as the working electrode in different pH phosphate buffered solutions. The experimental Standard redox potential, E°′, of Methyldopa is obtained to be 0.72 mV versus SHE (Standard Hydrogen Electrode). E°′ values have also been calculated with the a...

Alpha methyldopa has been shown to modify left ventricular mass and normalize mitochondria/myofibrils volume ratio in spontaneously hypertensive rats (SHR) when administered during the stage of developing cardiac hypertrophy (Tomanek et al., Cardiovas Res 23: 173, 1979). To evaluate the long-term effects of this antihypertensive agent, the drug was administered to SHR and normotensive (WKY) rat...

One hundred pregnant women with hypertension (defined as diastolic blood pressure at or above 95 mm Hg) were allocated at random to treatment with methyldopa or oxprenolol and were compared with nonhypertensive controls matched according to parity and gestation at delivery. The patients were also stratified into those entering the study early (before 32 weeks' gestation) and those entering late...

S ISCE t,he initial comm~~ni~ation of Oates etall reporting that methyldopa lowered blood pressure in hypertensive patients additional studies hal-e attested to the efficacy of this drug as an antihypertensi~e agent.‘-? Over the past 21/ years methyldopa (Aldome@) has been utilized in this clinic usuaily in conjunction with sulfonamide saluretic agents in the long-term treatment of hypertensive...

We present the case of a 40-year-old woman who experienced severe hypertension during her first pregnancy. Hypertension persisted after delivery, prompting admission to Department Endocrinology and Metabolism at our hospital. Examination revealed an aldosterone-producing adenoma, she was diagnosed with primary aldosteronism. Her controlled using methyldopa. She became pregnant again in April 20...