Abstract Background Clinical studies of anti-glomerular basement membrane (GBM) disease were limited because the low incidence. We aimed to report characteristics, treatments, and outcomes patients with anti-GBM at a tertiary reference medical center in Japan review literature mortality disease. Case presentation 1 was 72-year-old Japanese man that referred worsening serum creatinine (from 1.1 ...

The introduction of cortisone as an anti-inflammatory agent stimulated the search for newer steroids with greater anti-rheumatic effect, but with fewer associated side-reactions. Shortly afterwards, hydrocortisone became available, and, although its anti-rheumatic effect was slightly greater, undesirable physiological responses were more or less similar. Fried and Sabo (1953) synthesized a cort...

Glucocorticoids are frequently used to treat allergic reactions. Therefore, allergic reactions to systemic glucocorticoids in particular are considered most unlikely and are not well known. We report on a 23-year-old woman with atopic dermatitis who had an anaphylactic reaction after oral administration of prednisolone. On treatment with epinephrine, antihistamines and volume symptoms resolved....

Background: Catastrophic Antiphospholipid syndrome (CAPS) is a scarcely understood entity with a high mortality approaching 50%The rapid deterioration is triggered by a deadly cytokine storm, which is difficult to recognize and almost impossible to treat in time. Various regimens have been advocated, which include administration of monoclonal anti-phospholipid antibodies and pulses of high dose...

We report a case of a 28 year old female who presented with variedly progressive stroke like illness and raised intracranial pressure. Brain MRI scans revealed pericallosal and periventricular hyperintensities with oedema. Various medications like intravenous immunoglobulin, antibiotics, acyclovir, methyl prednisolone and management for raised intracranial pressure were instituted. She rapidly ...