Gastro retentive floating tablet of Simvastatin was prepared by direct compression technique using Methocel K4M as the rate controlling polymer. The hydrophilic cellulose derivative, Methocel K4M was evaluated for its gel forming and release controlling properties. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The effects of soluble components (sodium bicarbonat...

Floating matrix tablets of Cephalexin were prepared by using synthetic and natural polymers each in two different concentrations. The floating properties and in-vitro drug release properties were optimized and total 10 formulations were developed. The synthetic and natural polymers used were HPMC K4M, HPMC K15M and Guar Gum, Xanthan gum respectively. Each formulation consists of polymer in any ...

The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calor...

The viscoelastic behavior of polymer solutions is commonly measured using oscillating shear rheometry, however, the accuracy such methods limited by frequency equipment and since relaxation time dilute short, this requires measurement at very high frequencies. Microrheology has been proposed to overcome technical challenge. Yet for resolving statistics particle displacements in microrheology ex...

It has been proposed that lovastatin arrests cells in the G1-phase of the division cycle, and that release from lovastatin inhibition produces a synchronized culture. A new method of methocel time-lapse-videography has been used to analyse cell division patterns following lovastatin treatment. Release of L1210 cells from lovastatin inhibition failed to produce synchronized divisions. Moreover, ...

The present work deals with the development of a prolonged release matrix tablet readily soluble drug pramipexole. new excipient Kollidon SR (a mixture 80% polyvinyl acetate and 20% polyvinylpyrrolidone) hypromellose K15M were used as polymers to control from selected prototypes. Various polymer concentrations tested achieve stable pH independent pramipexole 0.26 mg over 24 hours; samples prepa...

The objective of this work was to study the dissolution process from piroxicam pellets, coated with Eudragit RS 30 D by fluidized bed, in order to achieve an enteric release of the drug. The coating product contains a methacrylic copolymer which is insoluble, but permeable. The drug-loaded pellets were prepared by extrusionspheronization using microcrystalline cellulose (Avicel PH 101) as a sph...

The present investigation studies the effect of water swellable polymer hydroxylpropylmethyl cellulose (HPMC K4M, Methocel) on in vitro release of ondansetron from suppositories. Suppositories were prepared by using mixture of Poloxamer 407 and Poloxamer 188 hydrophilic bases. Suppositories containing 16 mg of ondansetron were prepared by fusion method. Weight variation, content uniformity, bre...

Hydrophilic matrices are widely used for extended release drug delivery, with hypromellose (HPMC) being a popular rate-controlling carrier. The FDA has recently issued an alert regarding the potential negative influence of alcohol on extended release dosage forms. The aim of this study was to investigate the hydroalcoholic solution effect on hydration, gel formation and drug release from HPMC m...