Address for Correspondence: Halil Doğan, Department of Emergency, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey E-mail: [email protected] ©Copyright 2016 by Emergency Physicians Association of Turkey Available online at www.jemcr.org Introduction For erythrocytes, which contain hemoglobin, to carry oxygen to tissues, the iron content of hemoglobin should be in th...

Y OUNG INFANTS are unusually susceptible to the development of methemoglobinemia upon exposure to certain medications and toxic agents. Ingestion of well water containing large quantities of nitrate will cause methemoglobinemia in small babies while older members of the family remain unaffected.14 Bismuth subnitrate, benzocaine, resorcin or aniline dye, taken by mouth or absorbed rectally or pe...

methemoglobinemia is a disorder characterized by the presence of a higher than normal level of methemoglobin. prilocaine which is one of the oxidizing local anaesthetics is widely used in many local procedures. the first choice of treatment of complications due to the use of these local anaesthetics is methylene blue, while ascorbic acid is the alternative choice. the side effects of metilen bl...

By PHILIP L. TOWNES AND MARTIN MomusoN A VARIANT of hereditary methemoglobinemia exhibiting dominant inheritance of normal methemoglobin has recently been reported? Although the TPN and DPN methemoglobin reductases were found to be normal, an inability to utilize glucose for the reduction of methemoglobin was demonstrated. The present report describes further attempts to define more definitely ...

Rasburicase is frequently used in tumor lysis syndrome (TLS). Although it is very well tolerated, it can cause severe oxidative hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report another case of rasburicase-induced methemoglobinemia in a patient with previously unrecognized G6PD deficiency and review the cases of methemoglobine...

Rasburicase is frequently used in tumor lysis syndrome (TLS). Although it is very well tolerated, it can cause severe oxidative hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report another case of rasburicase-induced methemoglobinemia in a patient with previously unrecognized G6PD deficiency and review the cases of methemoglobine...

On behalf of the World Health Organization (WHO), I have undertaken a series of literature-based investigations examining the global burden of disease related to a number of environmental risk factors associated with drinking water. In this article I outline the investigation of drinking-water nitrate concentration and methemoglobinemia. The exposure assessment was based on levels of nitrate in...

Few health care professionals realize that topical anesthetic spray can cause methemoglobinemia. We describe a 56-year-old woman who was transferred to our emergency department when severe cyanosis and chest pain developed after administration of topical oropharyngeal benzocaine and lidocaine during outpatient endoscopy. Investigations revealed a methemoglobin level of 51%. Despite rapid diagno...

Aluminium phosphide (AlP) a grain fumigant is the leading cause of intentional poisoning in North India. The mechanisms involved in toxicity are not known and there is no antidote till date. The present study was carried out to investigate the oxygen free radical generation, methemoglobinemia and effect of methylene blue treatment on survival time in rat model of AlP poisoning. AlP (50 mg/kg, i...

Phenazopyridine is a commonly used urinary analgesic available throughout the United States. Ingestion of large quantities can lead to methemoglobinemia, hemolytic anemia, jaundice, and acute renal failure. We report a case of a 78-year-old male with previously normal renal function who developed acute renal failure and jaundice without methemoglobinemia or hyperbilirubinemia after taking nearl...