Background & Aims: Methadone maintenance therapy is one of the treatment choices for opiate users. Understanding opiate dependants’ experiences of their treatment period is important for continuing the treatment with methadone and assessing their experiences may help to revise the standards of methadone centers and thus to improve the quality of treatment. This study aims to describe the struct...

BACKGROUND Genetic variability in ABCB1, encoding the P-glycoprotein efflux transporter, has been linked to altered methadone maintenance treatment dose requirements. However, subsequent studies have indicated that additional environmental or genetic factors may confound ABCB1 pharmacogenetics in different methadone maintenance treatment settings. There is evidence that genetic variability in O...

The mental and physical capabilities of drivers in traffic are often seriously challenged these days. Not only do they need to concentrate on driving, predict connections between various phenomena, take appropriate judgements in current situations and foresee the sequence of measures to be taken, but they are also expected to be emotionally stable, etc. The problem with drugs in traffic is ofte...

Methadone maintenance treatment has been shown in many studies to reduce mortality and morbidity among heroin users. However, there has been concern that widespread methadone prescribing will lead conversely to an increase in methadone-related deaths. This study in Sheffield shows no increase in methadone-related mortality over a two-year period, during which 400 untreated patients were recruit...

Background: Needle sharing and sexual contacts Taiwanese Department of Health (DOH) among injecting drug users (IDUs) have become laden with HIV and HIV related health problems, representing a serious public health threat all over the world. For reduce the sharing of needle, Taiwanese public health prompted methadone maintenance treatment (MMT) to reduce needle sharing and curb the transmission...

Background: This comprehensive systematic review and meta-analysis were performed to assess the associated factors of maintenance in patients with methadone therapy in the world.Methods: A systematic literature review was performed from several scientific databases; these include PubMed, Scopus, ISI Web of Science, and MEDLINE. We searched the following keywords: “Methadone”, “Maintenance”, “Re...

The majority of opiate-dependent clients entering substance abuse treatment are referred to "drug-free" (non-methadone) modalities. Given the known challenges of treating these clients in drug-free settings relative to the documented effectiveness of methadone maintenance, these analyses investigate the availability of various clinical and wraparound services for this population among a US samp...

BACKGROUND This study aimed to investigate the initial dosage of methadone and factors affecting it in maintenance therapy. METHODS This cross-sectional, descriptive-analytic study was conducted on 157 individuals referring to a methadone maintenance therapy (MMT) clinic. The initial dosage of methadone was 20-45 mg which was adjusted during the treatment based on each patient's evaluation. T...