background: in this study we evaluated the prognostic impact of metastatic lymph node ratio (mlr) in patients with gastric cancer undergoing curative surgical resection. methods: a total of 121 patients with gastric adenocarcinoma undergoing curative r0 surgical resection in our institutions between 2003 and 2010 were included in this study.  mlr was classified into 3 groups as follows: mlr0; 0...

In 1889, the famous German Pathologist, Julius Cohnheim, postulated that the findings from tumor autopsy are explicable on natural principles. Within the next decade, members of the Johns Hopkins Hospital Medical Society with Dr. Flexner in the Chair dealt with a case that demonstrated the above dictum of Cohnheim. It is proposed here to appreciate historically what happened at the Meeting of F...

Synovial sarcomas are soft tissue neoplasms mostly located in the lower extremities of young adults. A case of synovial sarcoma of the thigh in a 35-year-old male with the predominant epithelial component is reported. Microscopically the tumor showed variable-sized well-differentiated glands lined by the cuboidal cells with small foci of spindle cell component between glandular structures...

The metastatic properties of tumor cell clones isolated from individual lesions of B16 melanoma metastatic to lung have been examined at different stages in the evolution of metastasis. Clonal analysis of metastatic lesions produced by B16 melanoma populations containing clones with identifiable, stable drug-resistance markers revealed that the majority (greater than 80%) of experimental metast...

Medulloblastomas present generally a-specifically as a fast-evolving posterior fossa tumor. Medical literature is poor concerning clinical features of medulloblastomas and their potential significance. In the study, we reviewed 91 pediatric observations treated in Lille between 1997 2017. Clinical epidemiological variables were collected intercorrelated. They also compared with anatomical patho...

Ovarian cancer most likely spreads into the peritoneal cavity or can be only superficially invasive. Although common metastatic pathway used by ovarian cells involves seeding, hematogenous and lymphatic dissemination also occur. Metastatic colorectal cancers arising from ovary are extremely rare. A mass colon wall at level of hepatic flexure was detected tomography during routine follow-up a pa...

Melanoma is originating from melanocytes, it a malignant tumor with high metastatic potential. It the leading cause of moratlity skin cancer, Nail melanoma rare form melanoma. we report new case this localization

Primary peritoneal tumors share a common anatomical site and therefore their clinical manifestations are very similar. When masses detected, the tentative initial diagnosis is secondary to metastatic disease, which has been determined most frequently in cavity. However, primary should always be included differential diagnosis. Among malignant neoplasms, mesothelial have identified (malignant me...

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

BACKGROUND BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary ccRCC, little is known regarding heterogeneity in metastatic ccRCC tumors. MATERIALS AND METHODS W...