The acute influence of NO2 on mechanics of breathing and respiratory gas exchange was investigated in a total of 111 subjects, aged 25 to 74 years, with chronic nonspecific lung disease (CNSLD). They breathed NO2-air mixtures containing 0.5 to 8.0 ppm NO2 for up to 15 to 60 min. Additionally in nine subjects the protective action of atropine, meclastine, and orciprenaline was investigated. Whil...

We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed. Adrenergic agonists increased erythrocyte carbonic anhydrase as follows: adrenaline by 75%, noradrenaline by 68%, isoprenaline by 55%, and orciprenaline by 62%. The kinetic data indicated a non-compet...

The action of beta- and alpha-adrenoceptor agonists (isoprenaline, orciprenaline, noradrenaline, phenylephrine and ephedrine) and antagonists (propranolol, metipranolol, exaprolol, BL 445 and phentolamine) on the resting tension and cAMP level of the guinea pig and the mechanical and electrical activities of the dog trachea were studied. By activating beta 2-adrenoceptors, isoprenaline and orci...

The first derivatives of the left ventricular pressure pulse (dp/dt LV) and of the apexcardiogram (A ACG) were recorded 73 times in 45 subjects, and the time intervals from the peak of the R wave of the electrocardiogram to the peak of the derivatives (t-dp/dt LV and t-A ACG) were determined under different circulatory conditions. These parameters express the duration of the development of maxi...

The first derivatives of the left ventricular pressure pulse (dp/dt LV) and of the apexcardiogram (A ACG) were recorded 73 times in 45 subjects, and the time intervals from the peak of the R wave of the electrocardiogram to the peak of the derivatives (t-dp/dt LV and t-A ACG) were determined under different circulatory conditions. These parameters express the duration of the development of maxi...

AIMS Although sinus node modification by catheter ablation is an established therapy for the treatment of inappropriate sinus tachycardia, there is incomplete understanding of sinus node anatomy and function but also limited electroanatomical mapping data. Recently, an automatic, ultra high-resolution mapping system has been presented to accurately and quickly identify right atrial (RA) geometr...

This study was performed to characterize the -adrenoceptor population in rabbit isolated corpus cavernosum (RbCC) by using nonselective and selective -adrenoceptor agonists and antagonists in functional assays. Metaproterenol, ritodrine, fenoterol, and 8-hydroxy-5-[(1R)-1-hydroxy-2-[N-[(1R)-2-( -methoxyphenyl)-1-methylethyl]amino]ethyl]carbostyril (TA 2005) (3–100 nmol each) dose dependently re...

We used intracellular microelectrodes to study the electrophysiological effects of combinations of components of ischemia and their relation to the occurrence of ventricular arrhythmias in the specialized conducting system of isolated canine right ventricles. The middle area of the free wall was exposed to various test solutions in the center compartment of a three-chambered bath; the base and ...

We investigated the effects of transforming growth factor a (TGF-a) on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes and examined the influence of a and b adrenoceptor agonists on the TGF-a-induced responses. TGF-a (1.0 ng/ml) produced a 4.1-fold elevation of DNA synthesis during 3 h of culture and a 1.2-fold increase in the nucleus number (proliferation) during 4...

notes the substantial benefit many children with moderate to severe chronic asthma derive from the use of steroid aerosols. However, it fails to emphasize the important place that regular use of bronchodilators has in management. It is inferred that if adequate control of asthma is not achieved with regular prophylactic disodium cromoglycate and bronchodilator therapy given early in the course ...