نتایج جستجو برای: metallothioneins
تعداد نتایج: 771 فیلتر نتایج به سال:
Each of the two domains of mammalian metallothioneins contains a zinc-thiolate cluster. Employing site-directed mutagenesis and chemical modification, fluorescent probes were introduced into human metallothionein (isoform 2) with minimal perturbations of the structures of these clusters. The resulting FRET (fluorescence resonance energy transfer) sensors are specific for each domain. The design...
OBJECTIVE To facilitate development of novel disease-modifying therapies for lysosomal storage disorder (LSDs) characterized by nervous system involvement such as metachromatic leukodystrophy (MLD), molecular markers for monitoring disease progression and therapeutic response are needed. To this end, we sought to identify blood transcripts associated with the progression of MLD. METHODS Genom...
The metallothioneins are a family of heavy-metal binding proteins of low molecular weight. They function in the regulation of trace metal metabolism and in the protection against toxic heavy metal ions. In man, the metallothioneins are encoded by at least 10-12 genes separated into two groups, MT-I and MT-II. To understand the genomic organization of these genes and their involvement in heredit...
Scientific research has focused to delineate the core aspects of stress tolerance mechanisms and apply crucial components for enhancing plants their growth under stressed environments. Metallothioneins (MTs) are known play pivotal roles in regulation. They bacteria, fungi, all other eukaryotic organisms. MTs low molecular weight, cysteinerich proteins. important metal chelators also possess ant...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید