chicken has been used as a suitable model for lipid metabolism studies, because dietary modifications especially dietary fat type can change chicken body composition. fats act as a condense source of energy and certain fatty acids such as polyunsaturated fatty acids (pufas) are required for both animal and human health. the n-3 pufas, especially, eicosapentaenoic acid (epa) and docosahexaenoic ...

In membrane-based water purification technology, control of the membrane pore structure is fundamental to defining its performance. The present study investigates effect preparation conditions on final size distribution and dye removal efficiency cellulose acetate membranes. membranes were fabricated by means phase inversion (using different speeds film casting thicknesses casted solution) intr...

Membrane modifications in sperm cells represent a key step in sperm capacitation; however, the molecular basis of these modifications is not fully understood. Ezrin is the best-studied member of the ezrin/radixin/merlin family. As a cross-linker between the cortical cytoskeleton and plasma membrane proteins, ezrin contributes to remodeling of the membrane surface structure. Furthermore, activat...

Over the past decade, Penetrating Keratoplasty (PKP) graft failure has been increasingly managed by Descemet Membrane Endothelial (DMEK). Moreover, Anterior Segment Optical Coherence Tomography (AS-OCT) is becoming as essential modality for perioperative evaluation. Our aim to share important surgical considerations and modifications based on preoperative evaluation using AS-OCT and, consequent...

Personalized medicine requires the development of a wide array of biomarker diagnostic assays, reflecting individual variations and thus allowing tailored therapeutic interventions. Membrane proteins comprise approximately 30% of total human proteins; they play a key role in various physiological functions and pathological conditions, although, currently, only a limited number of membrane prote...

Biomimetic forward osmosis membranes with a polyamide-based active layer containing polymersomes incorporating aquaporins were exposed to various free chlorine doses (free concentration x exposure time) and pH. Membrane chlorination was found decrease the apolar/polar balance of membrane surface energy increase its negative charge density. A substantial modification hydrogen-bond network in als...

Despite their location in the aqueous extracellular environment, a number of secreted proteins carry hydrophobic lipid modifications. These modifications include glycosylphosphatidylinositol, cholesterol, and both saturated and unsaturated fatty acids, and they are attached in the secretory pathway by different classes of enzymes. Lipid attachments make crucial contributions to protein function...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Src-family tyrosine kinases, which are expressed in various cell types, play critical roles in cell signalling at the cytoplasmic side of the plasma membrane through their lipid modifications. Src-family kinases are cotranslationally myristoylated and posttranslationally palmitoylated in the amino-terminal region. The Src-family member Lyn contains a myristoylation site at glycine-2 and a palmi...

Nine splenectomized, hematologically well-compensated beta-thalassemia intermedia patients randomly chosen from a pool of 60 similar patients were studied. Membrane proteins solubilized with nondenaturing detergent C12E8 were gel filtered on Sepharose CL-6B (Pharmacia Fine Chemicals, Uppsala, Sweden). Fractions containing higher than 4,000-kD molecular-weight aggregates were isolated and analyz...