A 33 year old man with acquired immunodeficiency syndrome developed a toxic megacolon. The patient was admitted with a two month history of diarrhoea. Cryptosporidia were isolated from all stool specimens. Clinically and radiographically he developed toxic dilatation of the colon which responded to conservative management.

Clinical Images A 21-year-old man presented with symptoms of fatigue that had been progressing for several months. The patient had a history of depression and childhood constipation. Physical examination revealed conjunctival pallor, abdominal distention, and left upper quadrant firmness. Laboratory tests were positive for fecal occult blood test and revealed a serum hemoglobin level of 0.0048 ...

A 56-year-old female with a prior medical history of congenital mental retardation, hypercholesterolemia, and hypothyroidism consulted for severe constipation refractory to laxatives, which required enemas for evacuation, associated with abdominal distension and weight loss –8 kg over the last six months–. Physical examination revealed a hard, long, rounded mass measuring 8 x 10 cm in the centr...

A morphometric study of the circular colon musculature was performed, in which the mast cell count was determined and the connective fibrous tissue in this layer was measured. The objective was to gain better understanding of Chagas megacolon morphology and contribute towards the knowledge of fibrosis pathogenesis in Chagas megas. An evaluation was made of 15 distal sigmoid rings from Chagas pa...

Klippel-Feil syndrome is a congenital abnormality characterized by the fusion of bones cervical spine. Its association with gastrointestinal rare. We report case 14-year-old girl affected associated megacolon. should be considered as any polymalformative and its management multidisciplinary.