Correspondence: Ming-Sheng Zhou Vascular Biology institute, University of Miami Miller School of Medicine, Nephrology-Hypertension Section, Veterans Affairs Medical Center, 1201 Nw 16 Street, Room A-1009, Miami, FL 33125, USA Tel +1 305 575 3103 Fax +1 305 575 3378 email [email protected] Abstract: A growing number of experimental and clinical studies have provided evidence indicating that p...

Multidimensional discrete data (MDD) { i.e., arrays of arbitrary size, dimension, and base type { appear in a variety of business, technical , and scientiic application elds. Ras-DaMan is an eeort to give comprehensive domain-independent MDD database support. Based on a formal algebraic array model, Ras-DaMan ooers declarative array operators embedded in standard SQL; key DBMS components are an...

Several lines of evidence suggest that hypertension and angiogenesis may be related phenomena but a functional link remains elusive. Here, we propose that the renin-angiotensin system (RAS), in addition to its central role in arterial hypertension, also regulates blood vessel formation during normal development and cancer. This mechanistic hypothesis is based on reports of biochemical, genetic,...

BACKGROUND RAS (KRAS and NRAS) testing is required to predict anti-epidermal growth factor receptor (EGFR) treatment efficacy in metastatic colorectal cancer (CRC). Although direct sequencing (DS) with manual microdissection (MMD) is widely used, a diagnostic kit providing rapid detections of RAS mutations would be clinically beneficial. We evaluated the MEBGEN(TM) RASKET KIT (RASKET KIT), a mu...

OBJECTIVE To evaluate the significance of BRAF (V600E) and Ras mutations, and RET rearrangements in papillary thyroid cancer (PTC) in the South central region of China. METHODS We included patients from Union hospital's pathology archive diagnosed with PTC and meeting the criteria for BRAF mutation, RAS mutation, and RET rearrangement testing. Medical records were analyzed for BRAF and RAS mu...

Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. This systematic review was conducted to evaluate the clinical effectiveness and security of laser treatment in RAS patients. Methods. Five electronic databases were searched (MEDLINE (PubMed), EMBASE,...

From the Department of Ophthalmology, NYU Langone Medical Center, Bellevue Hospital Center, and Manhattan Eye, Ear and Throat Hospital, New York, New York. The author has no financial or proprietary interest in the materials presented herein. Correspondence: Anna Escuder, MD, Department of Ophthalmology, NYU Langone Medical Center, 462 First Avenue, NBV 5N1-6, New York, NY 10016. E-mail: anna.e...

colorectal cancer (crc) is one of the most common cancers worldwide. understanding of the tumor behavior, in a much closer look, at the molecular level, results in a more effective treatment and accurate prognosis of the disease. from among various genes altered in colorectal cancer k-ras is assumed to be of diagnostic and prognostic significance. k-ras mutations are believed to be a critical e...

There are very few studies about K-ras mutations in colorectal cancer (CRC) from developing countries such as Iran. It is therefore essential to conduct studies to learn about the molecular signature of such tumors, allowing the determination of an appropriate management plan. In the present study, we aimed to determine the frequency and types of K-ras mutations among patients with CRC in Iran....