Adhesion receptors expressed on the surfaces of tumor-activated endothelial cells provide an advantageous locus for targeting gene therapy vectors to angiogenic tissues and/or tumor vasculature. In this study, we engineered a series of Asn-Gly-Arg (NGR)-containing congeners of the presumptive cell binding motif contained within the ninth type III repeat of fibronectin and displayed these tumor ...

Corticotropin releasing factor binding protein (CRF-BP) was originally recognized as CRF sequestering protein. However, its differential subcellular localization in different brain nuclei suggests that CRF-BP may have additional functions. There is evidence that CRF-BP potentiates CRF and urocortin 1 actions through CRF type 2 receptors (CRF2R). CRF2R is a G protein-coupled receptor (GPCR) that...

By Surgeon A. E. K. Stephens, Bengal Medical Service. 1. SuhJcur.?The wing received orders on the 21st November 1878 to march the nest day to Jacobabad for the purpose of performing escort duty from that place to Quetta. 2. Kahars Drill, &c.?The time at Sukkur, 9th November to the 22nd, had been devoted to drilling and exercising the doolie bearers in their work, showing them how to pick up the...

MENT NATIVE INFANTRY AND 7th BENGAL CAVALRY, MORAR. [The following papers, which give an accurate and complete account of a severe outbreak of cholera which took place in May last in a treasure escort composed of detachments of the 7th Bengal Cavalry and 41st Native Infantry, have been placed at our disposal by the Surgeon-General, Indian Medical Department. At the same time that the events whi...

Assembly of the bacterial flagellar filament requires a type III export pathway for ordered delivery of structural subunits from the cytosol to the cell surface. This is facilitated by transient interaction with chaperones that protect subunits and pilot them to dock at the membrane export ATPase complex. We reveal that the essential export protein FliJ has a novel chaperone escort function in ...

In nonextensive statistical mechanics, two kinds of definitions have been considered for expectation value of a physical quantity: one is the ordinary definition and the other is the normalized q-expectation value employing the escort distribution. Since both of them lead to the maximum-Tsallis-entropy distributions of a similar type, it is of crucial importance to determine which the correct p...

In simple crystalline materials, plastic deformation mostly takes place by the movement of dislocations. Although the underlying mechanisms in these materials are well explored, in complex metallic alloys--crystalline solids containing up to thousands of atoms per unit cell--the defects and deformation mechanisms remain essentially unknown. Owing to the large lattice parameters of these materia...

Methods of digital image analysis find wide application both in scientific research and many branches industry. During the last decades, interest has grown images with multifractal structure which are obtained biology, medicine, chemistry studying soil. The mathematics fractals fractal geometry well known studied. However, despite this, a common approach to designing methods practical investiga...