Severe hyperglycemia can result in falsely high results for mean cell (erythrocyte) volume (MCV), which will also cause false results for erythrocyte indices calculated on the basis of MCV. Falsely high MCV results were obtained with the Technicon H1 and H2 analyzers and (to a lesser extent) with the Coulter T660. The H analyzers were more susceptible to this interference than was the Coulter T...

Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase. Further investigation led to i...

The mean corpuscular volume (MCV) of peripheral blood mononuclear cells (PBMCs) was determined by Coulter Counter, and data were used to calculate the intracellular drug concentrations. A total of 574 PBMC samples were collected from 190 patients. The MCV was 282.9 fl (minimum, 207.0; maximum, 354.6), with a standard deviation of 8.8%. Previous reports have often used a fixed value of 400 fl fo...

Background: Molluscum contagiosum virus (MCV): is a viral skin infection which may infect themucous membrane and skinoccasionally, It is caused by Molluscipox virus from family Poxviridae. Molluscum contagiosumvirus (MCV) was first described and later assigned its name by Bateman in the beginning of the nineteenth century. Aim: This study was done to confirm the clinical diagnosis of MCV by lab...

The MCV (mean corpuscular volume) was examined by the Coulter model S. It was found that the MCV measured by the Coulter S was larger than the generally accepted range 82 to 92, or 76 to 96 mu(3). The range in 500 healthy individuals was 82.2 to 100.6 mu(3). It was also found that the mean MCV became larger with increasing age. No sex difference was found. The low MCV by manual methods was gene...

203 words) Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines demonstrate oncogene addiction to the MCV T-antigens, pharmacological interference of the large T-antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of interferons (I...

Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of approximately 80% of human Merkel cell carcinomas (MCCs). Transcript mapping was performed to show that MCV expresses transcripts in MCCs similar to large T (LT), small T (ST), and 17kT transcripts of SV40. Nine MCC tumor-derived LT genomic se...

Hemoglobin (Hb), mean cell volume (MCV), and erythrocyte protoporphyrin (EP) are commonly used to screen for iron deficiency (ID), but systematic evaluation of the sensitivity and specificity of these tests is limited. The objective of this study is to determine the sensitivity and specificity of Hb, MCV, and EP measurements in screening for ID in preschool children, non-pregnant women 15-49 ye...

M contagiosum virus (MCV) infection occurring in an epidermal cyst (EC) is a very rare condition and only a few cases were reported in children and adults.1-3 However, MCV in multiple small epidermal cysts (ECs) was not previously described. Therefore, this unusual case of molluscum infestation occurring in multiple ECs was presented. A 20-year-old female was evaluated with an asymptomatic, fir...

Adult patients with macrocytosis, defined as a mean corpuscular volume (MCV) greater than 100 femtoliters, were studied to assess the importance of an elevated MCV. After eliminating pregnant and postpartum patients and patients receiving medications known to cause macrocytosis (e.g., phenytoin, zidovudine, and chemotherapeutic agents), 80 patients were identified and studied. Sixty-seven diagn...