Introduction: Breast cancer (BC) is the most common women cancer worldwide. Radiotherapy and chemotherapy are the two common treatment options but these techniques suffer low selectivity and adverse effects on surrounding normal tissues. Non- ionizing pulsed electromagnetic fields (PEMFs) in ultra-narrow band frequency and intensity have shown anticancer effects. Changing potas...

Background: Molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7). The pattern of cell death in MCF-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

background & aim:breast cancer is the second most common cancer in women after lung cancer. given that the herbal ingredients are used for centuries to treat cancer,the aim of this study was to determine the cytotoxic effect of hydroalcholic extract from thymus daenesiscelak on mcf-7 cancer cells line. experimental: breast cancer cells mcf-7 and natural fibroblast cells were cultured in dmem me...

The oncogenic isoform of HER2, HER2Δ16, is expressed with HER2 in nearly 50% of HER2 positive breast tumors where HER2Δ16 drives metastasis and resistance to multiple therapeutic interventions including tamoxifen and trastuzumab. In recent years microRNAs have been shown to influence multiple aspects of tumorigenesis and tumor cell response to therapy. Accordingly, the HER2Δ16 oncogene alters m...

In the search for novel cytotoxic agents, sesquiterpenoids and phenylpropanoids have provided interesting lead compounds. From the chloroform extract of the underground parts of Laserpitium latifolium, the daucane sesquiterpenoids laserpitin and acetyldesoxodehydrolaserpitin, and the phenylpropanoids laserin and latifolon were isolated as the major compounds. Acetyldesoxodehydrolaserpitin is id...

BACKGROUND Marine sponge is a rich natural resource of many pharmacologically important compounds. OBJECTIVE Marine sponge Hyrtios erectus, collected from North Bay, South Andaman Sea, India, was screened for potential antiproliferative and proapoptotic properties on a breast adenocarcinoma cell line (MCF-7). MATERIALS AND METHODS 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...