Background The treat-to-target (T2T) concept is not yet a recognized treatment approach in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). Developing such recommendations an unmet medical need. Objectives To determine therapeutic targets develop GCA PMR. Methods We conducted systematic literature review to retrieve data on outcomes GCA/PMR as well identify the evidence for effectiv...

Background: GCA is characterized by cranial symptoms but imaging techniques show that patients with non-specific such as systemic inflammation or PMR may have undiagnosed large vessel (LV) 1 . Although silent in clinically isolated consequences for patients’ outcome, little known about its prevalence and characteristics of affected patients. Objectives: To review data on the newly diagnosed wit...

Human heart Na 1 channels were expressed transiently in both mammalian cells and Xenopus oocytes, and Na 1 currents measured using 150 mM intracellular Na 1 . Decreasing extracellular permeant ion concentration decreases outward Na 1 current at positive voltages while increasing the driving force for the current. This anomalous effect of permeant ion concentration, especially obvious in a mutan...

More than five decades ago Bruce Merrifield introduced the idea of automation to organic chemistry through the use of solid supports as an enabling technology that facilitates synthesis as well as work-up. The age of combinatorial chemistry popularized solid-phase-assisted synthesis, but also paved the way for new enabling technologies and technical devices such as liquid-handling systems, radi...

Since its discovery the rearrangement of R-metalated ethers, particularly the [2,3]-Wittig rearrangement, has been the subject of intensive mechanistic and synthetic investigations.1 Relative to the [2,3]-shift, the [1,2]-Wittig rearrangement has received relatively little publicity. Most studies of the [1,2]-Wittig have been mechanistic in origin, resulting in the widely accepted theory that t...

Soft skills are a collection of people management skills, important to many professions and job positions, including academic librarianship. Yet the concept of soft skills lacks definition, scope, instrumentation, and systematic education and training. This literature review explores the definition of soft skills; contrasts skills with related concepts, such as personality traits, attitudes, be...

Title: Sexual function and the surgical management of breast cancer Presenter: Michaela Onstad, MD, MPH Preceptor: Jennifer Gass, MD Other authors: Erin Kunkel, Melissa A. Clark, PhD, Vrishali Lopes, MS Objective: Women diagnosed with early stage breast cancer may be managed surgically with lumpectomy followed by radiation, mastectomy alone, or mastectomy with reconstructive procedures, all dem...

Ion channels are important in controlling cell cycle progression and proliferation in a variety of cell types. Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (Kras G12D ( / ), p53 R273C, p16), BxPC-3 (smad4 , p53 Y220C, p16), and MiaPaCa-2 [transforming growth factorreceptor type II defect, K-ras G12C...

The Golgi apparatus is a dynamic organdie whose structure is sensitive to vesicular traffic and to cell cycle control. We have examined the potential role for mbla, a GTPase previously associated with ER to Golgi and intra-Golgi transport, 'in the formation and maintenance of Golgi structure. Bacterially expressed, recombinant rabla protein was mieroinjected into rat embryonic fibroblasts, foll...

-   ahmadi, m., kaboli, m., imani harsini, j., khosravi sharifabadi, r., almasi, m., 2012. strategic management plan for wolf (canis lupus) in hamedan province: an approach to reducing human-wolf conflicts. journal of natural environment, iranian journal of natural resources. 65, 271–281. -   ballard, w.b., dau, j.r., 1983. characteristics of gray wolf, canis lupus, den and rendezvous sites in ...