Stroke is one of the leading causes death and disability worldwide. However, treatment options for ischemic stroke remain limited. Matrix-metalloproteinases (MMPs) contribute to brain damage during strokes by disrupting blood-brain barrier (BBB) causing edemas. Carnosine, an endogenous dipeptide, was found us others be protective against injury. In this study, we investigated whether carnosine ...

matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

Due to their unusual ability to cleave and degrade a variety of ECM components, including triple-helical type IV collagen, two members of the family of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are thought to play critical roles during tumor invasion and metastasis. The proteolytic activity of mature MMPs is modulated by a group of specific inhibitors, the tissue inhibitors of metallop...

Vascular smooth muscle cell (SMC) migration is a critical step in the development of neointima after angioplasty. Matrix metalloproteinases (MMPs) degrade the basement membrane and the extracellular matrix, facilitating SMC migration. Transfer of the endothelial nitric oxide synthase (eNOS) gene to the injury site inhibits neointima formation. Neither the signaling pathways leading to NO-mediat...

Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The present study determined the levels of GCF matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) and salivary MMP-8 in patients with gingivitis and periodontitis and in healthy controls. Levels of crevicula...

Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...

Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) members MMPs that show promise as potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins patients with BC. consi...

BACKGROUND AND PURPOSE Excessive degradation of the vascular matrix by matrix metalloproteinases (MMPs) can lead to structural instability of vessels. In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs). METHODS We performed gelatin zymography for MMPs and Western blot for MMP-9, MMP-2, TIMP-1, TIMP-...

Introduction: Exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. The aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (VEGF) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( MMP-2 and MMP-9), as the degradi...

During tissue-invasive events, migrating cells penetrate type I collagen-rich interstitial tissues by mobilizing undefined proteolytic enzymes. To screen for members of the matrix metalloproteinase (MMP) family that mediate collagen-invasive activity, an in vitro model system was developed wherein MDCK cells were stably transfected to overexpress each of ten different MMPs that have been linked...