objective(s): osteoarthritis (oa), as a known degenerative joint disease, is the most common form of arthritis. in this study, we aimed to elucidate unclear pathogenesis of oa. materials and methods: rabbit models of oa were established by the transection of the anterior cruciate ligament. rabbits were randomly divided into three equal groups: the experimental group (oa modeling, treated with e...

Background/aims. Matrix metalloproteinases are major contributors in the breakdown and reconstitution of basement membranes and extracellular matrix in pathophysiological processes. We assessed the expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel disease. Patients/methods. Resected tissue specimens from patients with Crohn’s disease or ul...

this study was conducted to examine if allergic contact dermatitis (acd) alters the expression of mmps in human dermal fibroblasts. fibroblasts are the primary source for mmp and matrix production in skin. mmps are known to involve in a number of physiological and pathological processes. some published data indicated a gelatinase-like activity in acute and chronic phases of allergic contact der...

controversial immunomodulatory properties of bee venom (bv) have provided an appropriate field for more investigation. the aim of present research was to verify the effects of honeybee venom on matrix metalloproteinase activity and interferon production as well as cell proliferation in monocyte and fibroblast cell lines. the monocyte and fibroblast cell lines (k562, ht-1080, wehi-164) were used...

The aim of this paper was to reveal the latest clinical and research findings regarding the implications of MMP2 and MMP9 matrix metalloproteinases in retinoblastoma development. The targets were finding better options for the therapeutic approach, considering the etiopathogeny and biology of this tumor.