Maternal malnutrition during lactation reduces prolactin (PRL) and milk production, alters milk composition, and programs the body weight of the offspring. Our study aimed to evaluate the long-term effects of maternal hypoprolactinemia at the end of lactation on food ingestion, body weight, amount of retroperitoneal white adipose tissue (RPWAT), leptinemia, and anorectic leptin effect in the ad...

Objective Postpartum weight retention (PPWR), which refers to the value of postpartum minus pre-pregnancy weight, is a common problem among women after childbirth. The main objectives this study are understand changes in body breastfeeding mothers during long-term follow-up and preliminarily explore relationship between maternal human milk composition, including macronutri...

The prediction of birth weight may be improved by the measurement of hormones or growth factors in the mother. We measured body weight (BW) and plasma levels of placental GH (PGH), IGF-I, IGF-binding protein-1 (IGFBP-1), and leptin at the time of the glucose challenge test (GCT) in 289 women, who were pregnant with a single fetus, between 24 and 29 wk gestational age (GA). Delivery occurred 12 ...

Epidemiological and animal studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development can contribute to development of metabolic syndrome in adulthood. In this paper, we investigated the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received a HF or a contr...

BACKGROUND Low birth weight (BW), small head circumference, reduced length, increased preterm births and neuro-endocrine dysfunctions are among known consequences of smoking during pregnancy. Few studies have linked leptin to clinical features of growth restriction associated with maternal smoking and explored interaction with other determinants of size at birth, such as gender. METHODS Cord ...

Amaç: Maternal beden kütle indeksinin anne sütündeki leptin, ghrelin, adiponektin ve IGF-1 düzeylerine etkisini belirlemek bu hormonların bebeğin büyümesi ile ilişkisini değerlendirmektir.
 
 Gereç Yöntemler: Bu araştırmaya Ankara Çocuk Sağlığı Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesine başvuran, 2 aylık bebeği olan bebeğine sadece sütü veren, 20 normal vücut ağırlı...

Maternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately exercised and we observed the effects of this aerobic exercise on their prepubertal and adult of...

OBJECTIVE To examine associations of perinatal and 3-year leptin with weight gain and adiposity through 7 years. DESIGN AND METHODS In Project Viva, plasma leptin from mothers at 26-28 weeks' gestation (n = 893), umbilical cord vein at delivery (n = 540), and children at 3 years (n = 510) was assessed in relation to BMI z-score, waist circumference, skinfold thicknesses, and dual X-ray absorp...

The aim of this study was to determine the release and regulation of leptin, resistin and adiponectin from human placenta and fetal membranes, and maternal subcutaneous adipose tissue and skeletal muscle obtained from normal and gestational diabetes mellitus (GDM)-complicated pregnancies at the time of Cesarean section. Tissue explants were incubated in the absence (basal control) or presence o...

OBJECTIVE The role of first trimester maternal body mass index (BMI) and adipocytokines in cord blood c-peptide and birth weight in pregnancy was investigated. DESIGN Seventy non-diabetic pregnant Caucasian women were recruited. Anthropometry and measurements of fasting adipocytokines (visfatin, leptin, adiponectin), insulin and glucose were performed in each of the three trimesters. At birth...