Oxygen dissociation curves of maternal and fetal bloods prepared in vitro have been described in several species including the goat.' The use of recent polarographic methods for measuring oxygen tension in blood avoids any possible alteration in oxygen affinity of the blood during equilibration in tonometers and could theoretically result in more accurate maternal and fetal oxygen dissociation ...

Background: Current prenatal diagnosis requires invasive testing which carries a 1-4% procedure-related-risk of miscarriage; hence, non-invasive techniques are desired. The recent demonstration of cell-free-fetal-DNA enriched from maternal plasma has opened new possibilities for non-invasive-prenatal-diagnosis of not only genetic-disorders such as β-thalassaemia and haemophilia but also chromos...

context maternal serum human chorionic gonadotropin (hcg) and alpha fetal protein (afp) were originally introduced to detect trisomy 21 and neural tube defects. however, in the absence of aneuploidy or neural tube defects, mid-trimester maternal serum hcg and/or maternal serum afp associated with adverse pregnancy outcomes. pregnancies with unexplained mid-trimester elevation in maternal serum ...

Maternal fetal leakage (FMH) is a well-known cause of anemia. We define it as the transition erythrocytes into maternal circulation. Its severity determined by measuring level hemoglobin in mother's blood using Kleinhauer-Betke test or cytometric method (FCM). The paper presents case newborn with massive maternal-fetal leakage. Kleinhauer result was greater than 5% cells, and initial neonatal 3...

Background: It is well documented that fetal DNA can cross the placenta and is present in peripheral maternal blood during pregnancy in human. This fetal DNA also named circulating cell free fetal DNA, has emerged as a valuable source for genetic evaluation. Compared with humans, ovine species have a different structure of placental (synepitheliochorial) with no direct contact between the troph...

Background & aim: One of the factors of affecting maternal anxiety is a history of fetal death or neonatal death. This anxiety affects fetal and maternal health. By consideration the impact of anxiety on fetal and maternal health and the lack of protective activities in this field, this study was done to determine the impact of adaptation with pregnancy educational package on anxiety and matern...

OBJECTIVES Leg length is the component of stature most sensitive to early life nutrition; as such, it provides an opportunity to retrospectively evaluate the relationship between a woman's infancy and early childhood nutrition and offspring birth weight (BW). Here we explore the relationship between maternal leg length and offspring BW in a rural Philippine community, while also investigating t...

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent developmental toxicant in rodents, and these effects occur at exposures similar to background human body burdens. A physiologically based pharmacokinetic (PBPK) model can aid in quantitatively describing the relationship between exposure, dose, and response. The aim of this work was the development a PBPK model to describe the relationship ...