This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites. Relevant synthetic studies on the deep-sea natural products have also been included.

Address correspondence to: Abel Baerga-Ortiz, Ph D, Assistant Professor, Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, PO Box 365067, San Juan Puerto Rico 00936. tel: 787-758-2525 ext. 1603 • Fax: 787-274-8724 • email: [email protected] Marine ecosystems are a source of biologically active compounds, many of which are currently in clinical use. With the goal o...