Depression, as one of the largest influence disorders, needs more attention on its growing patients. Medicine treatment has been seeing major for depression. As most commonly used medicine, Selective Serotonin Reuptake Inhibitors (SSRIS) increases serotonin levels to treat depression effectively, and data from clinical prove value. Furthermore, Norepinephrine (SNRIs) Monoamine Oxidase (MAOIs) b...

Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...

Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...

BACKGROUND Antidepressant-induced extrapyramidal symptoms (EPS) represent an underrecognized but important clinical entity. We reviewed the literature on new antidepressants and conducted an analysis of cases from the FDA Adverse Event Reporting System (AERS), which has not been published before. METHODS A literature review was conducted using PubMed, Ovid, MEDLINE, PsycINFO, and the Cochrane...

The serotonin syndrome is a toxic state largely attributable to changes in sensitivity of serotonin receptor system in the brainstem and spinal cord resulting from increased serotonergic activity in central neurologic system, due to use of serotonergic agents either in overdose or in combination. Serotonin syndrome may present with neuromuscular (clonus, myoclonus, tremor, hyperreflexia) and au...

Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitor (SNRIs) for this condition have been widely accepted, but they were challenged by unacceptable side-effects, potential drug-drug intera...

Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge. Method: An electronic search was conducted through Medline, Pubmed, Cochrane library, and ScienceDirect. Forty nine empirical researches were identified and reviewed. Results: Amitriptyline, clomipramine, and mirtazapine have been ...

Affective disorders are a group of psychiatric diseases that can affect an individual at any given age. Also called mood disorders, they can be distinguished into two different types: major depressive disorder, also called major depression, and bipolar disorder, which is known as manic depression. People affected by major depression most often have a low mood, and are consistently in a state of...

The purpose of this study was to explore the prescribing practices in a sample of physicians in the treatment of depression and to what degree these practices reflect research findings. 224 of 300 selected physicians (75%) responded to a 11-item questionnaire covering four major content areas: first-line preferences in the treatment of depression, antidepressant agents most associated with cert...

Your question brings up a couple of different, complicated issues. First, in regards to your inquiry about the dangers of mixing Dexatrim (an over-the-counter weight loss supplement) and Prozac (generic name: fluoxetine), it may help to know that fluoxetine isn't in the antidepressant class of monoamine oxidase inhibitors (MAOIs). Rather, it's a selective serotonin reuptake inhibitor (SSRI). Ne...