In this paper, the problem of batch scheduling in a flexible flow shop environment is studied. It is assumed that machines in some stages are able to process a number of jobs simultaneously. The applications of this problem can be found in various industries including spring and wire manufacturing and in auto industry. A mixed integer programming formulation of the problem is presented and it i...

In this paper, the problem of batch scheduling in a flexible flow shop environment is studied. It is assumed that machines in some stages are able to process a number of jobs simultaneously. The applications of this problem can be found in various industries including spring and wire manufacturing and in auto industry. A mixed integer programming formulation of the problem is presented and it i...

this research provides an optimization tool for use by supply chain managers in the design and operation of manufacturing- distribution networks under uncertain demand conditions. the problem under consideration consists of determining the supply chain infrastructure; raw material purchases, shipments, and inventories; and finished product production quantities, inventories, and shipments neede...

To compare several promising product designs manufacturers must measure their performance under multiple environmental conditions In many applications a product design is considered to be seriously awed if its performance is poor for any level of the environmental factor For example if a particular automobile battery design does not function well under temperature extremes then a manufacturer m...

Sustained and controlled pellets are considered as one of the ideal dosage forms. Due to the large coverage area of pellets, loaded drugs can be absorbed completely in the body and bioavailability is improved correspondingly. Coated pellets-containing tablet is a special oral formulation consisting of various pellets with different release rate. Desired rate of drug release rate can be achieved...

To compare several promising product designs, manufacturers must measure their performance under multiple environmental conditions. In many applications, a product design is considered to be seriously flawed if its performance is poor under any level of the environmental factor. For example, if a particular automobile battery design does not function well under some temperature conditions, then...

We propose a complete methodology to develop custom monofocal Intraocular Lens (IOL) designs and evaluate their performance on-axis based on an analytical formulation. The analytical formulation was based on Gaussian and primary aberration theory applied to custom (individual biometric data) and realistic (multilayer cornea and thick IOL) pseudoaphakic eye models. Gradient-based optimization al...

The state-of-the-art treatment for hemophilia A is replacement therapy with recombinant factor VIII (rFVIII) made possible by genetic engineering advances. Currently, there are four different products licensed and available for hemophilia A patients. All are produced by recombinant mammalian cells in large-scale fermenter cultures, purified to high purity, formulated in stable formulations and ...

We describe a synthesis system that takes operating range constraints and inter and intracircuit parametric manufacturing variations into account while designing a sized and biased analog circuit. Previous approaches to computer-aided design for analog circuit synthesis have concentrated on nominal analog circuit design, and subsequent optimization of these circuits for statistical fluctuations...