Manic depressive illness is a common and frequently debilitating familial psychiatric disorder. Efforts to understand the mechanisms of inheritance have been hindered by the complexity of the phenotype, which may range from benign mood swings to chronic psychosis, and by apparently nonmendelian modes of transmission. Early reports of linkage to chromosomal loci have fallen into doubt; however t...

The phenomenology of mania has not been empirically studied adequately. Various studies have revealed 2. 4 & 5 factors as the core features defining the manic state. Differences in the Bipolar disorders have been reported across culture in the past further complicating the issue.This study was carried out to study the core features of the manic state and compare it with similar studies across c...

Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine extended-release capsules (CBZ-ERC) are a recent formulation of CBZ approved by the US Food and Drug Administration in 2004 for the treatment of acute manic and mixed episodes associated with bipolar I disorder. This new formulation was developed to improve dosing convenience and decrease daily fluctuatio...

---------------------------INDICATIONS AND USAGE---------------------------ABILIFY is an atypical antipsychotic indicated as oral formulations for the: Treatment of schizophrenia (1.1) • Adults: Efficacy was established in four 4-6 week trials and one maintenance trial in patients with schizophrenia (14.1) • Adolescents (ages 13-17): Efficacy was established in one 6-week trial in patients with...

One of the innovations in ICD-11 section "schizophrenia and other primary psychotic disorders" is implementation 6 additional domains, which should improve diagnosis treatment these conditions. Cariprazine a new atypical antipsychotic with predominant affinity for D3 receptors, registered Russia schizophrenia, mania, mixed depressive episodes bipolar I disorder. In modern algorithms schizophren...

SUMMARY The new diagnostic category in the Depressive Disorders chapter of DSM-5 entitled 'Major Depressive Disorder With Mixed Features' is applied to individuals who meet criteria for Major Depressive Disorder and have concurrent subsyndromal hypomanic or manic symptoms. But the operational definition of this new specifier is much closer to that of hypomania and mania than to the definition o...

Manic (n = 26), schizophrenic (n = 26), and normal (n = 25) subjects were examined with a digit span distraction task and with a reality monitoring task. All subjects were tested twice at a 4-day interval, and a clinical assessment of thought disorder was conducted both times on the patients. We found that reality monitoring, distraction task performance, and clinical thought disorder were all ...

Bipolar disorder is a brain illness that causes mood, energy, and ability to function variations. patients have extreme emotional states often occur over period of days weeks, referred as mood episodes. Manic/hypomanic (abnormally cheerful or angry mood) depressed (sad episodes are classified. People with bipolar frequently periods neutral mood. can live long productive lives if they treated. T...

OBJECTIVES Bipolar type II (BP II) disorder is thought to be distinct from BP I disorder on genetic and biological grounds, and it is not merely a milder form of the illness. It affects 1.5-2.5% of the US adult population, and is characterized by highly recurrent depressive episodes with a substantial morbidity from alcoholism and non-affective psychopathology, and a higher suicide rate than ei...

Cariprazine is a new therapeutic agent recently approved for the treatment of both schizophrenia and manic or mixed episodes associated with bipolar disorder, and is under investigation for the treatment of both bipolar depression and major depressive disorder.