A disease in which the lesions have a characteristic histological appearance consisting of epithelioid cell tubercles, as a rule clearly defined within the affected tissue, with only slight round cell infiltration in their vicinity, without central caseation, with or without Langhan's type giant cells, and with or without peculiar inclusion bodies within these cells, proceeding in the older les...

The incidence, morbid anatomy, histology, and relationship of hyaline pleural plaques to exposure to asbestos has been studied. Plaques were found in 12.3% of 334 hospital necropsies (in an urban population in Glasgow, 41 cases). In 85.3% (35 cases) asbestos bodies were found in the lungs. There is evidence of a dose-response relationship between the number of asbestos bodies found in the lungs...

THE first reference in the literature to hemispherical bodies is that of von Hippel (1928) who, in describing the histological appearances of a glaucomatous eye, wrote: "hemispherical figures in Bowman's membrane are numerous, their significance unknown" (Fig. 1). Similar bodies were later observed by Wolff and Lyle (1937) in sections from an eye with old traumatic retinal detachment and second...

Although the presence of giant cells in any type of lesion in leprosy is not a rarity, the presence of inclusions in their cytoplasm is infrequent. We do not refer to the fatty content in the category of inclusions, but to the bodies known as cytoplasmic inclusions of Wolbach (12) and those of Schaumann (10). Wolbach described and depicted, with photomicrographs and colored drawings, intracellu...

Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestosome-1 (p62), which is a common component of cytoplasmic aggregates in a variety of protein aggregation diseases. In contrast to the well-established...