Central nervous system (CNS) malformations represent important factor of morbidity and mortality in children. The aim of the study was to determine the incidence, type and clinical features of CNS malformations in children who were admitted at the Neonatal and Child Neurology Department, Neonatal Intensive Care Unit and Paediatric Intensive Care Unit of Paediatric Clinic, University of Sarajevo...

Children between 0-6 years of age from six villages of Ambala District were screened for congenital malformations. Of 1371 children, malformations were observed in 30 (prevalence 22/1000). Twenty children had major malformations and six had multiple anomalies. Cardiovascular malformations were the commonest (37%) followed by musculoskeletal (30%), gastrointestinal (23%), central nervous system ...

Our aim was to study the incidence and outcome of antenatally detected renal malformations in rural Maharashtra. Among 7365 deliveries conducted during the study period, antenatal screening for renal malformations was done in 6682 (90.7 %) deliveries. Renal malformations were detected in 35 fetuses on antenatal screening. Postnatal investigations confirmed renal malformations in 27 babies (77.1...

UNLABELLED Congenital heart malformations represent a public health problem, holding a significant percentage of the total of heart diseases. Beside the elevated frequency of the malformations, we also notice their occurrence in newborn babies with low birth weight, increasing, thus, the risk of complications and late therapeutic approach. The goal of the study was to highlight the general and ...

Among 1195 twins born in the Collaborative Perinatal Project, for whom information was available, 219 (18.33%) were found to have malformations, 179 (14.98%) single and 40 (3.35%) multiple. The frequency of malformations and malformed individuals was significantly higher in twins than in singletons from the same population but the difference was entirely contributed by MZ twins. This held true ...

The roles of the Notch pathway proteins in normal adult vascular physiology and the pathogenesis of brain arteriovenous malformations are not well-understood. Notch 1 and 4 have been detected in human and mutant mice vascular malformations respectively. Although mutations in the human Notch 3 gene caused a genetic form of vascular stroke and dementia, its role in arteriovenous malformations dev...

Hereditary haemorrhagic telangiectasia (HHT) is characterized by the development of arteriovenous malformations--enlarged shunts allowing arterial flow to bypass capillaries and enter directly into veins. HHT is caused by mutations in ALK1 or Endoglin; however, the majority of arteriovenous malformations are idiopathic and arise spontaneously. Idiopathic arteriovenous malformations differ from ...

[This corrects the article on p. 60 in vol. 3, PMID: 27896269.].

Malformations of cortical development (MCD) have been increasingly identified. The purpose of this presentation is to review the current knowledge of the MCD. Before we address this issue, we will briefly present a review of cortical development. The second part of this presentation will address the most important MCD. Finally, the last part of this presentation will address the correlation bet...