Tunicamycin, an antibiotic that inhibits the transfer of N-acetyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol monophosphate and thereby blocks the formation of protein-carbohydrate linkages of the N-glycosidic type, is not a single compound but a mixture of homologous antibiotics. Two major and eight minor homologs have been identified, all of which possess the ability to inh...

The empirical analysis of multiproduct pricing suffers from a lack of clear theoretical guidance and appropriate data, limitations which often render traditional regression-based analyses impractical. This paper analyzes ticket, parking, and concession pricing in Major League Baseball for the period 1991-2003 using a new methodology based on principal components, which allows inferences to be f...

The late David Brower [1], a noted environmentalist, stated “We don’t inherit the environment from our ancestors, we borrow it from our children”. This is a very sobering comment. If the definition of sustainability is that we leave this planet to our children in a better state than we found it, then according to the Intergovernmental Panel on Climate Change (IPCC) [2] we are failing dismally. ...

Today, ridesharing is attracting more and more attention due to its high potential in reducing the greenhouse gas emissions and decreasing the amount of traffic in the streets. The paper extends the earlier presented approach to building sustainable logistics system for ridesharing support based on the idea of smart spaces, where various electronic devices can seamlessly access all required inf...

Fine particles were simultaneously collected at an urban, industrial and coastal site in Tianjin, China from December 28, 2006 to January 31, 2007 to investigate the chemical characteristics of major PM2.5 components during an annually occurring season of high pollution. Water-soluble inorganic ions, organic carbon (OC) and elemental carbon (EC) were analyzed. Daily average concentrations of PM...

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A new method of determining the oligosaccharide composition of commercial glycosaminoglycan heparin is described in which heparin was first depolymerized using heparin lyase (EC 4.2.2.7), and then analysed by a single h.p.l.c. step. All 20 of the porcine and bovine heparins examined were found to contain a small number of major oligosaccharide components, which on average comprised 86% of their...

BACKGROUND The Hamilton Depression Rating Scale (HDRS) is widely used to measure the severity of depression in mood disorders. Total HDRS score correlates with brain metabolism as measured by fludeoxyglucose F 18 ([(18)F]-FDG) positron emission tomography. The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism. OBJECTIV...

Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B(His47Arg) and ALDH2(Glu487Lys) have dramatic effects on the rate of met...