The combination of magnetic hyperthermia therapy with the controlled release of chemotherapeutic agents in tumors may be an efficient therapeutic with few side effects because the bioavailability, tolerance and amount of the drug can be optimized. Here, we prepared magnetoliposomes consisting of magnetite nanoparticle cores and the anticancer drug gemcitabine encapsulated by a phospholipid bila...

Quantum dots (QDs) and silica nanoparticles (SNs) are new classes of fluorescent probes that overcome the limitations encountered by organic fluorophores in bioassay and biological imaging applications. We encapsulated QDs and SNs into liposomes and separated nanoparticle-loaded liposomes from unencapsulated nanoparticles by size exclusion chromatography. Fluorescence correlation spectroscopy w...

Au nanoparticle surface plasmon resonance-induced photocatalytic chemoselective oxidation of alcohols to carbonyl compounds has been investigated. The heterosupramolecular system consisting of Au nanoparticle-loaded titanium(IV) dioxide and surfactant molecular assembly dramatically enhances the reaction. This system should evolve the photocatalyst to intelligent nanodevices.

Microbubbles have shown potential as intralymphatic ultrasound contrast agents while nanoparticle-loaded microbubbles are increasingly investigated for ultrasound-triggered drug and gene delivery. To explore whether mRNA-nanoparticle loaded microbubbles could serve as theranostics for detection of and mRNA transfer to the lymph nodes, we investigate the behavior of unloaded and mRNA-loaded micr...

Hyperthermia has been suggested as a novel, minimally invasive cancer treatment method. After implantation of magnetic nano- or microparticles around a tumour through blood vessels, irradiation with alternating magnetic fields facilitates the efficient in situ hyperthermia even for deep-seated tumours. On the basis of this idea, if the microspheres are capable of delivering drugs, they could be...

Introduction: Inflammation plays a critical role in the progression of atherosclerosis. Novel iron-based nanoparticle platforms may allow noninvasive high-field MRI detection of vascular macrophages in mouse arteries. Purpose: To evaluate two novel nanoparticle platforms – magnetite incorporated human ferritin protein cages (HFn-Fe) and graphite/FeCo core-shell nanocrystals (G-FeCo) – for MRI o...

Background: The progress in material science and the recent advances in biodegradable/biocompatible polymers and magnetic iron oxide nanoparticles have led to develop innovative diagnostic and therapeutic strategies for diseases based on multifunctional nanoparticles, which include contrast medium for magnetic resonance imaging, agent for hyperthermia and nanocarriers for targeted drug delivery...

Both ionic and nanoparticle iron have been proposed as materials to control multidrug-resistant (MDR) bacteria. However, the potential bacteria evolve resistance remains unexplored. To this end, experimental evolution was utilized produce five magnetite nanoparticle-resistant (FeNP1–5) populations of Escherichia coli. The were not exposed nanoparticles. 24-h growth these replicates evaluated in...

Magnetotactic bacteria have evolved complex subcellular machinery to construct linear chains of magnetite nanocrystals that allow the host cell to sense direction. Each mixed-valent iron nanoparticle is mineralized from soluble iron within a membrane-encapsulated vesicle termed the magnetosome, which serves as a specialized compartment that regulates the iron, redox, and pH environment of the g...