Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation. Advanced heart failure (HF) patients with higher abundance of CCR2+ macrophages are more likely experience adverse remodeling. The precise mechanism in how they affect the progression dilated cardiomyopathy remains unknown. Metho...

two groups of antibodies against mouse resident alveolar and peritoneal macrophages have been raised individually in rabbits by immunization with whole cell suspensions of lavaged alveolar and peritoneal macrophages. the whole antisera reacted positively with neutrophils and lymphocytes. however, upon extensive absorptions with these cells the activity became restricted to macrophages. the immu...

the role of alveolar macrophages in the production of granulocyte/ macrophage colony-stimulating factor(s) by the rat lung was investigated. lavaged lungs, when incubated at proper weight per volume of culture medium, produced the same amount of colony-stimulating factor as unlavaged ones. both lavaged and unlavaged lungs produced similar types of colony-stimulating factor (s). prolonged incuba...

introduction: toxoplasma gondii is an obligatory interacelullar parasite that infects nucleated cells in its intermediate hosts. the aim of the present study was to determine the effect of vitamin d3 on the multiplication of t. gondii in peritoneal macrophage of balb/c mice and nitric oxide production by macrophages.  methods: according to usage of vitamin d3 (one dose or seven doses) and infγ ...

background: it has been shown that inhalation of carbonaceous particulate matter may impair lung function in children. objective: using the carbon content of airway macrophages as a marker of individual exposure to particulate matter derived from fossil fuel, we sought direct evidence for this association. methods: 300 children from puffed rice industrial areas and 300 children from population ...

One of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. In this study the effect of the male hormone 5a-DHT on cytokine release by peritoneal macrophages (mΦ) of male and female NZB/BALBc mice was investigated. Macrophages from male mice activated with LPS produced a greater amount of IL-1β (21.8%) (p<0.05) and IL-...

Macrophages’ role in the evolution of solid tumours is a well accepted fact, with M1-like macrophages having an anti-tumour and M2-like pro-tumour role. Despite fact that some clinical studies on lung have emphasised also presence mixed M1 M2 phenotypes addition to distinct phenotypes, majority still use M1-M2 classification predict patient survival. In this theoretical study we mathematical mo...

BackgroundNonsteroidal anti-inflammatory drug–exacerbated respiratory disease (N-ERD) is a chronic inflammatory condition, which driven by an aberrant arachidonic acid metabolism. Macrophages are major producers of metabolites and subject to metabolic reprogramming, but they have been neglected in N-ERD.ObjectiveThis study sought elucidate potential epigenetic macrophage reprogramming N-ERD.Met...