Two novel macrocyclic polyamine ligands and their dinuclear zinc (II) complexes were synthesized and characterized. Their interaction with plasmid DNA was studied by gel electrophoresis and fluorescence quenching experiment. The result showed that these complexes could bind DNA efficiently under physiological conditions.

The ring size effect of macrocyclic TMC ligands in nonheme iron(IV)-oxo complexes has been examined in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions; an iron(IV)-oxo complex bearing a smaller TMC ligand is more reactive in both HAT and OAT reactions, resulting from its high Fe(IV/III) redox potential.

Preorganizing a ligand in the conformation it adopts upon binding to a protein has long been considered to be an effective way to improve affinity by making the binding entropy more favorable. However, recent thermodynamic studies of a series of complexes of the Grb2 SH2 domain with peptide analogues having constrained and flexible replacements for a phosphotyrosine residue revealed that less f...

Three metallosupramolecular assemblies composed of two bis-NHCs and silver atoms, [4](PF6)2, tetra-NHCs four [7](PF6)4, tri-NHCs three atoms [8](BF4)3, have been prepared. Assemblies [4](PF6)2 [7](PF6)4 feature NHC ligands decorated with terminal olefin groups. Irradiation yielded complex [5](PF6)2 cyclobutane rings linking the bis-NHC ligands. Liberation macrocyclic tetrakisimidazolium salt H4...

Tetraazacyclododecane and tetraazacyclotetradecane derivatives bearing a spirobenzopyran and three carboxymethyl moieties, 1 and 2, and a diethylenetriamine derivative bearing a spirobenzopyran and four carboxymethyl moieties 3 were synthesized. The isomerization behaviors based on the spirobenzopyran moiety of these ligands were studied by UV-visible spectrophotometry in aqueous solutions cont...

Macrocyclic ligands form highly selective and kinetically labile complexes with a wide range of cations, including alkali metal and alkaline earth cations. Formation rate constants are high and remarkably insensitive to ligand structure, but decrease systematically with increasing charge density of the cation this behaviour is qualitatively similar to that expected for the dissociative intercha...

Library Generation Analysis and Combinatorial Chemistry: dedicated to Bruce Merrifield 1 Bruce Merrifield Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components 3 Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands 5 Oxor...