This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.

OBJECTIVE The aim of this study was to investigate how head and neck squamous cell carcinoma (HNSCC) tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device respond to radiation treatment. STUDY DESIGN Feasibility study. SETTING Tertiary referral center. SUBJECTS AND METHODS Thirty-five patients with HNSCC were recruited, and liver tissue from 5 Wis...

Cytokines play an important role in the onset, regulation, and propagation of immune and inflammatory responses within the central nervous system (CNS). The main source of cytokines in the CNS are microglial cells. Under inflammatory conditions, microglial cells are capable of producing pro- and antiinflammatory cytokines, which convey essential impact on the glial and neuronal environment. One...

INTRODUCTION Insulin analogues have gained widespread popularity. However, in many countries the use of these drugs is limited by their relatively high cost, so there is still a need for more cost-effective human insulin therapies. The aim of the study was to assess the effectiveness and safety of the premixed recombinant human insulin (rhuI) Gensulin M30 in a real-life setting. MATERIAL AND ...

Two sets of supramolecular rhenium carbonyl-phenanthroline complexes were prepared: fac-[Re(Cl)(CO)(3)(N,N)] and fac-[Re(Etpy)(CO)(3)(N,N)](+), where N,N is 2,9-di-anisyl-1,10-phenanthroline (dap) or two related macrocyclic ligands, where the two anisyl groups are connected by a polyether chain of different length and rigidity (m27, m30), which wraps around and above the equatorial Re(CO)(2) gr...

Downloa pose: We hypothesized that the basal apoptotic rate (BAR) of a cancer would predict sensitivity sequent proapoptotic stimuli. To explore this, preclinical and clinical BAR assays were developed ring cumulative apoptotic events through ELISAs for soluble caspase-cleaved cytokeratin 18 (M30) lized to either cell number increase or total tumor volume, respectively. erimental Design: The BA...

This research work focuses on the effect of natural caryota urens plant fiber as reinforcement strength properties concrete different grade. Fiber length 10 mm, 20 mm and 30 were added to mix at an amount 3% binder content. Three lengths fibers fixed volume fraction M30, M40 M50 grades concrete. The workability characteristics mechanical property twelve reinforced mixes investigated. post crack...

PURPOSE This study evaluated the prognostic value of pro and antiapoptotic protein expression, as well as that of spontaneous apoptosis, in anal carcinoma patients treated by radiotherapy (RT) with or without chemotherapy. EXPERIMENTAL DESIGN Ninety-eight patients with available pretreatment biopsy specimens were studied. Patients had been treated with split-course RT: 30-40 Gy fractionated e...

CONTEXT Data on cardiovascular risk (CVR) score among HIV-infected patients in sub-Saharan Africa are scarce. Our first objective was to compare the CVR score of Framingham utilizing BMI and lipids at baseline, and secondary to assess evolution of CVR score over time at Month 30 in the Temprano trial. METHODS HIV-infected adults with CD4 <800/mm3 without criteria for initiating ART were inclu...