We investigate the impact of the 766.3 Ty KamLAND spectrum data on the determination of the solar neutrino oscillation parameters. We show that the observed spectrum distortion in the KamLAND experiment firmly establishes ∆m21 to lie in the low-LMA solution region. The high-LMA solution is excluded at more than 4σ by the global solar neutrino and KamLAND spectrum data. The maximal solar neutrin...

The relationship between the cellular internalization of an anti-ganglioside GD2 monoclonal antibody (14.G2a) and the toxic effect of its ricin A-chain immunotoxin (14.G2a-RA) was examined on GD2-bearing M21 human melanoma and T293 small cell lung carcinoma cell lines. The capacity for ligand uptake was determined by examining the parameters that contribute to this constant, including the numbe...

Endophytic fungi have been recognized as possible useful sources of bioactive metabolites. However, exopolysaccharide (EPS) production from endophytic fungi and its antitumor activity have been less explored. In the present study, endophtic fungus Bionectria ochroleuca M21 was exploited for the production of EPS in submerged culture. Among tested medium components, glucose, yeast extract, MgSO4...

Microtubules are a proven target for anticancer drug development because they are critical for mitotic spindle formation and the separation of chromosomes at mitosis. 2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone (HL66) induced cell death with the large cells and multiple micronuclei in M21 skin cancer cells. We demonstrated that HL66-induced cell death is caspase-independent and accompan...

We report here our studies on the ¡nhibitionaleffect of 45°Cheat shock on transcriptions! and translational activity and their subsequent recovery at 37°Cin Rat-1 cells, thermotolerant Rat-1 cells ('IT Rat-1), and Rat-1 cells transfected with human hsp70 gene (IIR24, M21). Specifically, we ask whether overexpression of hspTOprotects cells from heat-induced inhibition in RNA and protein synth...

The pharmacokinetics and metabolism of valdecoxib, a potent cyclooxygenase-2 selective inhibitor, were investigated in mice. Valdecoxib was extensively metabolized after a single 5 mg/kg oral administration of [(14)C]valdecoxib and elimination of unchanged drug was minor (less than 1%) in male and female mice. The total mean percentage of administered radioactive dose recovered was 99.8% in the...

The isolated perfused rat kidney (IPK) was used to study the acute effects of cyclosporin A (CsA) and its metabolites (M1, M17, M18, M21 and M-COOH). GFR, renal vascular resistance, and sodium, potassium and water reabsorption were measured before and after the addition of CsA/metabolites/vehicles. There was no difference in CsA effect (mild decrease in GFR and increase in renal vascular resist...

The vacuum oscillation (VO) solution to the solar anomaly requires an extremely small neutrino mass splitting, ∆m2sol < ∼ 10 −10 eV. We study under which circumstances this small splitting (whatever its origin) is or is not spoiled by radiative corrections. The results depend dramatically on the type of neutrino spectrum. If m21 ∼ m22 > ∼ m23, radiative corrections always induce too large mass ...

Assuming three flavour neutrino mixing takes place in vacuum, we investigate the possibility that the solar νe take part in MSW transitions in the Sun due to ∆m31 ∼ (10 −7 − 10−4) eV 2, followed by long wave length vacuum oscillations on the way to the Earth, triggered by ∆m21 (or ∆m 2 32) ∼ (10−12 − 10−10) eV 2, ∆m31 and ∆m 2 21 (∆m 2 32) being the corresponding neutrino mass squared differenc...