In this issue of Blood, Fhu et al report that Reed-Sternberg cell-derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (cHL), a process that is regulated by cyclooxygenase/nuclear factor-κB/activator protein 1 signaling pathways.

Accumulating evidence suggests that high-endothelial venules (HEVs) represent major gateways for the infiltration of lymphocytes within neoplastic lesions. However, the origin of these vessels in human neoplasms remains elusive. We have recently discovered a link between lymphotoxin β-producing dendritic cells and tumor-associated HEVs.

Role of Lymphotoxin in Experimental Models of Infectious Diseases: Potential Benefits and Risks of a Therapeutic Inhibition of the LymphotoxinReceptor Pathway Thomas W. Spahn,* Hans-Pietro Eugster, Adriano Fontana, Wolfram Domschke, and Torsten Kucharzik Department of Medicine B, Münster University Hospital, Münster, Germany, and Section of Clinical Immunology, University Hospital Zürich, Zuric...

http://bloodjournal.hematologylibrary.org/content/100/5/1721.full.html Updated information and services can be found at: (4939 articles) Immunobiology • (1086 articles) Gene Expression • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts o...

Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses in patients with multiple sclerosis (MS) have established that B cells play a role in the pathophysiology of MS relapses. The same treatment appears not to impact antibodies directed against the central nervous system, which underscores the contribution of antibody-independent functions of B cells to d...

Capsule Background: Lymphotoxin-alpha (LTA) is involved in the pathogenesis of atherosclerosis. Results: The P2Y2 nucleotide receptor (P2Y2R) recruits filamin A to activate Rho signaling upstream of LTA secretion leading to intercellular cell adhesion molecule-1 expression. Conclusion: P2Y2R regulates LTA gene activation and secretion in vascular smooth muscle cells. Significance: This suggests...