Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by inflammation, and intraepithelial infiltration of eosinophils in the esophageal epithelium. It associated with unbearable symptoms, such as dysphagia, bolus impaction which affect nutritional status, quality life patients. diagnosed from thorough medical history, confirmed endoscopy biopsy. Traditionally, it h...

Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important surv...

background: genistein (gen), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. objective: the potential immunomodulatory effects of genistein on the immune system and against tc-1 tumor cell line were evaluated in adult female c57bl/6 mice. methods: mice were treated with gen 10 days before to 10 days after the tumor indu...

PROBLEM Little is known about immunological recovery in post-partum women and if lactational status affects immunocompetence. Many physiological changes occur, such as uterine involution and recovery of non-pregnant immune status. These changes may also affect susceptibility to disease. METHOD The study compared immune and inflammatory activation markers (serum cytokines, Epstein Barr viral a...

Elevated levels of type I interferon (IFN) during type 1 diabetes mellitus (T1D) are associated with a defective immune response. In the present study, we investigated whether blocking type I IFN signaling during streptozotocin- (STZ-) induced T1D in mice improves lymphocyte proliferation and escape from continuous apoptosis. Three groups of mice were examined: diabetic mice, type I IFN signali...

Thymomodulin (TMD), a thymic biological response modifier, stimulates the release of tumour necrosis factor (TNF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) in macrophage-lymphocyte cultures. We investigated the effects of the cytokines released in cultures with TMD, on the expression of human leucocyte antigen-DR (HLA-DR) antigens by alveolar macrophages (AM) and the T-cell ...

Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease. Here, we show that the development of the disease is dependent on both major histocompatibility complex (MHC) II-restricte...

Although the use of vitamin D analogues in the treatment of psoriasis has been an important new development, the mechanisms of action of these drugs are not fully understood. Psoriasis results from hyperproliferation of keratinocytes, and various studies attribute a crucial role to the locally infiltrating T lymphocytes. In an attempt to add to the understanding of the mechanisms of calcitriol ...