نتایج جستجو برای: lymphatic metastasis

تعداد نتایج: 147018  

2017
Kan Tanabe Yoshinari Shinsato Tatsuhiko Furukawa Yoshiaki Kita Kazuhito Hatanaka Kentaro Minami Kohichi Kawahara Masatatsu Yamamoto Kenji Baba Shinichiro Mori Yasuto Uchikado Kosei Maemura Akihide Tanimoto Shoji Natsugoe

To establish treatments to improve the prognosis of cancer patients, it is necessary to find new targets to control metastasis. We found that expression of FilaminC (FLNC), a member of the actin binding and cross-linking filamin protein family is correlated with lymphatic invasion and lymphatic metastasis in esophageal squamous cell carcinoma (ESCC) by increasing cell motility through activatio...

Journal: :Cancer cell 2012
Tara Karnezis Ramin Shayan Carol Caesar Sally Roufail Nicole C Harris Kathryn Ardipradja You Fang Zhang Steven P Williams Rae H Farnsworth Ming G Chai Thusitha W T Rupasinghe Dedreia L Tull Megan E Baldwin Erica K Sloan Stephen B Fox Marc G Achen Steven A Stacker

Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D that are secreted by some primary tumors. We identified regulation of PGDH, the key enzyme in prostaglandin catabolism, in endothelial cells of collecting lymphatics, as a key molecular change during VEGF-D-driven tumor spread. The VEGF-D-dependent regulation of the prostaglandin pathway was supported by the...

2016
Keun-Yong Eom Min Hye Jang So Yeon Park Eun Young Kang Sung Won Kim Jee Hyun Kim Jae-Sung Kim In Ah Kim

PURPOSE The aim of study was to test by immunohistochemical (IHC) staining whether carbonic anhydrase (CA) 9 and 12 have an effect on sentinel lymph node (SLN) metastasis in early breast cancer and to find clinicopathologic factors associated with SLN metastasis. MATERIALS AND METHODS Between June 2003 and June 2011, medical records of 470 patients diagnosed with breast cancer with pT1-2, pN0...

2017
Lauren M. Habenicht Sara B. Kirschbaum Momoko Furuya Maria I. Harrell Alanna Ruddell

The lymphatic vasculature collects and drains fluid and cells from the periphery through lymph nodes (LNs) for immune monitoring, and then returns lymph to the bloodstream. During immune responses LNs enlarge and remodel, featuring extensive growth of lymphatic sinuses (lymphangiogenesis). This LN lymphangiogenesis also arises in cancer, and is associated with altered lymph drainage through LNs...

2016
Liping Liu Chenglin Yang Jianfei Shen Liyan Huang Weixuan Lin Hailing Tang Wenhua Liang Wenlong Shao Haibo Zhang Jianxing He

Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABRA3 induced MMP-2 and MMP-9 expression through ac...

Journal: :The Tohoku journal of experimental medicine 2015
Masahiko Kito Satoru Motoyama Kazuma Fujita Masatomo Miura Hiroshi Nanjo Naoki Sato Dai Shimizu Toshiharu Sato Kenichi Makino Tae Sugawara Aya Kato Daisuke Tamura Kazue Takahashi Yukiyo Kumazawa Wataru Sato Hiroshi Miura Hiromitsu Shirasawa Akira Sato Jin Kumagai Yukihiro Terada

Endometrial cancer (EC) rates are rising in Japan. Lymph node (LN) metastasis is an important prognostic factor in EC, and its risk is increased with higher tumor grade, deep myometrial invasion, larger tumor size, and lymphovascular space invasion (LVSI). Current methodologies to assess these factors are unreliable. We previously showed the association between C-reactive protein (CRP) 1846C>T ...

Journal: :International journal of oncology 2012
Zhong-Yan Liu Hai-Ou Qiu Xiao-Jian Yuan Yan-Yan Ni Jian-Jun Sun Wei Jing Yue-Zu Fan

Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor properties in several cell lines and xenograft tumor models. However, its...

2017
Qingsong Luo Chongzhi Gan Xuehai Wang Li Gang

Objective: To investigate clinical characteristics and prognostic factors of patients with lymph nodes metastasis (LNM) of thoracic esophageal squamous cell carcinoma (ESCC) so as to provide reference basis for the clinical prevention and treatment of LNM of thoracic ESCC. Methods: Through a retrospective analysis on the clinical and follow-up data collected from 96 patients with LNM of thoraci...

2017
Yukiharu Todo Sho Takeshita Kazuhira Okamoto Katsushige Yamashiro Hidenori Kato

OBJECTIVE The aim of this study was to confirm the incidence and implications of a lymphatic spread pattern involving para-aortic lymph node (PAN) metastasis in the absence of pelvic lymph node (PLN) metastasis in patients with endometrial cancer. METHODS We carried out a retrospective chart review of 380 patients with endometrial cancer treated by surgery including PLN dissection and PAN dis...

Journal: :Cancer research 2006
Arvind P Pathak Dmitri Artemov Michal Neeman Zaver M Bhujwalla

Interactions between the tumor stromal compartment and cancer cells play an important role in the spread of cancer. In this study, we have used noninvasive in vivo magnetic resonance imaging (MRI) of two human breast cancer models with significantly different invasiveness, to quantify and understand the role of interstitial fluid transport, lymphatic-convective drain, and vascularization in the...

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