نتایج جستجو برای: lupus
تعداد نتایج: 42708 فیلتر نتایج به سال:
introduction systemic lupus erythematous (sle) is among rheumatic diseases of unknown etiology. fever of unknown origin (fuo) has been rarely reported to be the presenting sign of sle. presence of four or more sle criteria is diagnostic for the disease. however, presentations may occur serially which make it much more difficult to diagnose an already questioned fuo. case presentation our case o...
background: the aim of this study was to investigate the prevalence and associated factors of glucocorticoid-induced diabetes mellitus (gidm) in patients with systemic lupus erythematosus (sle) under glucocorticoid therapy. methods: patients with sle who had received high-dose glucocorticoid therapy (prednisolone≥1 mg/kg/day) at rasoul akram and firoozgar hospitals were recruited during 2006-20...
background: in lupus nephritis (ln), deposition of pathogenic autoantibodies in the glomeruli is mediated via cross-reactivity with alpha-actinin. association of serum alpha-actinin antibody (aαa) with ln has been shown in a few studies but the results are controversial. methods: eighty patients into entered the study. the diagnosis of sle was confirmed according to the american college of rheu...
Nocardiosis is a rare infection that in more frequent in patients with systemic lupus Erythematosus and its clinical manifestations are nonspecific.while concurrent treatment by corticosteroids is an independent risk factor for nocardiosis it increases both diagnostic and mangement problems.this article presents a 35 years old woman who has systemic lupus Erythematosus.she was hospitalized due ...
Background: Systemic lupus erythematous is an autoimmune disease associated with atherosclerotic manifestations or metabolic disturbance due to inflammation. The aim of this study was to determine frequency of metabolic syndrome (MetS) in SLE compared to healthy controls. Methods: In this cross-sectional study, 150 SLE patients and 220 healthy volunteers were enrolled. MetS was diagnosed acc...
Systemic lupus erythematosus is a chronic relapsing autoimmune disease that primarily afflicts women, and both a genetic predisposition and appropriate environmental exposures are required for lupus to develop and flare. The genetic requirement is evidenced by an increased concordance in identical twins and by the validation of at least 35 single-nucleotide polymorphisms predisposing patients t...
Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis-predisposing loci. Through genotyping and imputation, >1.6 million markers w...
Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunological consequences, particularly in the context of pre-existing lupus. IgG ant...
OBJECTIVE Several confirmed genetic susceptibility loci for lupus have been described. To date, no clear evidence for genetic epistasis in lupus has been established. The aim of this study was to test for gene-gene interactions in a number of known lupus susceptibility loci. METHODS Eighteen single-nucleotide polymorphisms tagging independent and confirmed lupus susceptibility loci were genot...
Nearly one half of patients with lupus develop glomerulonephritis (GN), which often leads to renal failure. Although nephritis is diagnosed by the presence of proteinuria, the pathology of nephritis can fall into one of five classes defined by different forms of tissue injury, and the mechanisms involved in pathogenesis are not completely understood. Glycosphingolipids are abundant in the kidne...
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