background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...

objective(s): increasing cytokines and reactive oxygen species (ros) during ischemia reperfusion (i-r) leads to the lung damage. adalimumab (ada) is a potent tumor necrosis factor-alpha (tnf-α) inhibitor agent. we aimed to evaluate whether ada would prevent the lung tissue from damage development over the i-r process. materials and methods:twenty seven wistar albino male rats were divided into ...

This paper presents four cases of abnormal soft tissue activity in the bone scan of patients with different lesions (lung inflammatory pseudotumor, pulmonary fibrosis, pulmonary metastatic osteosarcoma and metastatic hepatic carcinoma of colon).

Abstract Innate lymphoid cells (ILCs) are sentinels of healthy organ function, yet it is unknown how ILCs adapt to distinct anatomical niches within tissues. Here, we used a unique humanized mouse model, MISTRG mice transplanted with human hematopoietic stem and progenitor (HSPCs), define the gene signatures in vascular versus tissue (extravascular) compartment lung. Single-cell RNA-sequencing ...

alpha-1antitrypsin (a1at) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. one of the treatment strategies to provide appropriate and adequate concentrations of a1at in the lungsis the application of nanoparticles (nps) in pulmonary drug delivery. in the current study, biocompatible nanohydrogels were...

objective: amiodarone as an iodinated benzofuran derivative is a potent antiarrhythmic agent currently used for the treatment of ventricular arrhythmias. pulmonary toxicity is one of the complications of amiodarone therapy. the aim of this study was to determine the toxicity of amiodarone for pneumocytes. materials and methods: 14 male white new zealand rabbits were divided in a control group a...