Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection; however, there are still unanswered questions concerning SARS-CoV pathogenesis. We have shown that STAT1 plays an important role in the severity ...

Elevated levels of several endothelial markers, including CD31, VEGFR-2, ICAM-1, VCAM-1, E-selectin, P-selectin and vWF, in lung tissue circulation support an important role the pulmonary endothelium local systemic COVID-19 pathologyhttps://bit.ly/3eQObIR

Objective(s):Bone marrow-derived mesenchymal stem cells (BMSCs) have attracted significant interest to treat asthma and its complication. In this study, the effects of BMSCs on lung pathology and inflammation in an ovalbumin-induced asthma model in mouse were examined. Materials and Methods:BALB/c mice were divided into three groups: control group (animals were not sensitized), asthma group (an...

Objective: The effects of Portulaca oleracea (P. oleracea; PO) on total and differential WBC count, and oxidant/antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) as well as on lung pathology in asthmatic rats were examined. Methods and Methods: Rats were randomly divided into; control group (C), asthma group, asthma groups treated with either P. oleracea (rats that received P...

Objective: The effects of Portulaca oleracea (P. oleracea; PO) on total and differential WBC count, and oxidant/antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) as well as on lung pathology in asthmatic rats were examined. Methods and Methods: Rats were randomly divided into; control group (C), asthma group, asthma groups treated with either P. oleracea (rats that received P...

I read with interest the report of mucinous (so-called colloid) carcinoma of the lung by Dr. Rossi and colleagues (Am J Surg Pathol Vol. 28, April 2004). They attribute the first reported case of what was probably a mucinous cystadenoma of lung to Gowar in 1978, and note subsequent reports of mucinous or colloid carcinomas of lung. In fact, I believe the first report of primary mucinous (gelati...