An analysis of the effects of surgery on the function of the esophagus and lower esophageal sphincter (LES)b is complicated by the many variables that must be addressed. These include the technical aspects of the fundoplication itself (laparoscopic vs. open, complete vs. partial wrap, closure of the crura, etc.), the interval between operation and assessment, and the preoperative esophageal fun...

BACKGROUND Through rhythmic variations, the diaphragm influence lower esophageal sphincter (LES) pressure acting as an external sphincter. LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. AIM To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increa...

Hot and cold water, in comparison to room temperature water, ingested by normal young men, profoundly alters esophageal motor function. Cold water slows or abolishes esophageal peristalsis, prolongs the contraction wave in the distal esophagus, produces a delayed but prolonged relaxation of the lower esophageal sphincter, and regularly causes a lower esophageal sphincteric contraction of increa...

OBJECTIVE Ginger has been traditionally used to reduce intestinal gas and flatulence. The present study examined the effects of ginger on the esophagus and lower esophageal sphincter (LES) function by esophageal manometry. STUDY DESIGN A randomized controlled trial. SETTING Departments of Physiology and Medicine, Faculty of Medicine Siriraj Hospital. SUBJECTS Fourteen healthy young male v...

Esophagogastric junction outflow obstruction (EGJOO) is a rare but increasingly recognized diagnosis as described by The Chicago Classification of Esophageal Motility Disorders version 3.0 (version 3.0).1 On high-resolution manometry (HRM), EGJOO characterized increased integrated relaxation pressure (IRP) the lower esophageal sphincter (LES), yet with some preserved peristalsis.2–4 Little cons...

Esophageal achalasia is a primary motility disorder characterized by impaired lower esophageal sphincter relaxation and absence of esophageal peristalsis leading to impaired bolus transit, manifested with symptoms such as dysphagia, regurgitation, retrosternal pain, and weight loss. The standard diagnostic tool is esophageal manometry which demonstrates incomplete relaxation of the lower esopha...

AIM To compare expression of Ca(2+)-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS Sarcoplasmic reticulum Ca(2+) ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats...