Increase of inhibitor-2 of protein phosphatase-2A [Formula: see text] is associated with protein phosphatase-2A (PP2A) inhibition and tau hyperphosphorylation in Alzheimer's disease (AD). Down-regulating [Formula: see text] attenuated amyloidogenesis and improved the cognitive functions in transgenic mice expressing amyloid precursor protein (tg2576). Here, we found that silencing [Formula: see...

Background: Formula-fed infants have growth and plasma amino acid patterns different from those of breastfed infants. Objective: -Lactalbumin is a major protein in human milk, and the addition of bovine -lactalbumin to infant formula has been proposed to modify the plasma amino acid pattern of the recipient infant, possibly allowing a reduction in the protein content of the formula, which may a...

Phenylketonuria (PKU) is caused by deficient activity of the enzyme phenylalanine hydroxylase, needed to convert the essential amino acid (AA) phenylalanine (phe) to tyrosine. In order to prevent neurological damage, lifelong adherence to a low-phe diet that is restricted in natural foods and requires ingestion of a phe-free AA formula to meet protein needs is required. The goal of nutritional ...

This study investigated the acceptability of two very-low-calorie diets in 16 moderately overweight persons participating in a weight reduction program. Subjects were prescribed a 1000-1200 kcal balanced diet the first month and asked to complete appetite and mood scales on a weekly basis. They were then randomly assigned to either a protein-sparingmodified fast (PSMF) or a protein-formula-liqu...

Sakihara T, Otsuji K, Arakaki Y, Hamada Sugiura S, Ito K. Randomized trial of early infant formula introduction to prevent cow's milk allergy. J Allergy Clin Immunol 2020:S0091-6749(20)31225-2. What is the therapeutic efficacy (CMF) compared with none, in preventing allergy (CMA) among 1-2 month-old babies? Randomized, controlled (RCT). 4 hospitals Okinawa, Japan. Babies, at least 2000g, 35 wee...

BACKGROUND Plasma threonine concentrations are elevated in infants fed formula containing a whey-to-casein protein ratio of 60:40 compared with concentrations in infants fed formula containing a ratio of 20:80 or human milk (60:40). OBJECTIVE We studied whether degradation of excess threonine was lower in formula-fed infants than in infants fed their mothers' milk. DESIGN Threonine kinetics...