OBJECTIVE Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma octreotide levels have decreased over time in patients receiving these doses of...

The presence of high levels of arsenic (As) in rice fields has negative effects on the health of those consuming rice as their subsistence food. This study determined the variation in total As concentration in local aromatic rice (LAR) (kalijira) and two high-yielding varieties (HYVs) (BRRI dhan 32 and BRRI dhan 28) grown in paddy fields in Matlab, Bangladesh, an As hotspot with elevated As lev...

Laparoscopic-assisted rectal resection (LAR) has been widely used to treat rectal cancer. However, it has a steep learning curve. In this study, we aimed to investigate the effects of the learning curve on the outcomes of LAR. All consecutive patients with rectal cancer undergoing LAR or open resection (OR) between 2010 and 2015 were included in this retrospective analysis. The learning curve w...

Introduction: The zoning patterns of light lithophile elements (LLEs: Li, Be, B) in pyroxenes of some Martian meteorites have been used to suggest that the parent basalts were water-saturated, which exsolved and lost an aqueous phase through degassing and eruption, causing depletion in LLEs in the pyroxene rims [1]. In contrast, other investigators have suggested a diffusion controlled fraction...

[This corrects the article DOI: 10.1371/journal.pone.0160091.].

The double stapling technique is indispensable in low anterior resection for colorectal cancer. However, to prevent local recurrences due to the driving of cancer cells into the anastomosis. Intraluminal lavage should be performed.

Modern soil mapping is characterised by the need to interpolate point referenced (geostatistical) observations and the availability of large numbers of environmental characteristics for consideration as covariates to aid this interpolation. Modelling tasks of this nature also occur in other fields such as biogeography and environmental science. This analysis employs the Least Angle Regression (...